3-Chloropyridine (CAS 626-60-8) is a halogenated pyridine derivative widely used in pharmaceuticals, agrochemicals, and organic synthesis. Key parameters:
Parameter | Specification |
---|---|
Molecular Formula | C5H4ClN |
Purity | ≥99% |
Appearance | Colorless to pale yellow liquid |
Boiling Point | 148-150°C |
Density | 1.205 g/cm³ |
Storage | 2-8°C in airtight container |
Primary industrial applications include:
Compound | Reactivity | Stability | Typical Use Cases |
---|---|---|---|
3-Chloropyridine | High | Moderate | Pharma intermediates |
2-Chloropyridine | Moderate | High | Agrochemical synthesis |
4-Chloropyridine | Low | High | Research chemicals |
Typical Reaction Conditions:
Case 1: European Pharma Manufacturer
Challenge: Develop novel H1-antagonist with improved bioavailability
Solution: Used 3-chloropyridine as key intermediate in piperidine derivatization
Outcome: 40% yield improvement vs traditional routes
Case 2: Indian Agrochemical Company
Requirement: Cost-effective synthesis of chloronicotinyl insecticide
Implementation: 3-chloropyridine-based pathway optimization
Results: Production costs reduced by 22% annually
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