4-Hydroxy-6-aminopyrimidine: Comprehensive Guide & Industry Applications

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 4-Hydroxy-6-aminopyrimidine 4-Aminopyrimidine 6-Hydroxypyrimidine
CAS Number 5467-70-9 1072-86-4 1004-41-5
Molecular Formula C4H5N3O C4H5N3 C4H4N2O
Purity Grade ≥99% (Pharmaceutical Grade) ≥97% (Industrial Grade)
Thermal Stability Stable up to 250°C Decomposes at 180°C Decomposes at 160°C

2. Industrial Applications & Functional Roles

2.1 Pharmaceutical Intermediates

Critical component in synthesizing kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents. Enables precise molecular modifications in lead compound optimization.

2.2 Agrochemical Formulations

Key precursor for systemic herbicides and fungicides with enhanced plant mobility and residual activity. Compatible with modern slow-release formulations.

2.3 Advanced Material Synthesis

Building block for conductive polymers and coordination complexes in organic electronics. Enables π-π stacking in supramolecular architectures.

3. Handling Protocols & Storage Requirements

Parameter Specification
Storage Temperature 2-8°C (desiccated environment)
Solubility Profile DMSO: 50 mg/mL
Water: <1 mg/mL (pH dependent)
Incompatible Materials Strong oxidizers, acid chlorides

4. Implementation Case Studies

Case 1: Oncology Drug Development

Challenge: Achieve selective kinase inhibition in triple-negative breast cancer models
Solution: Structural modification using 4-Hydroxy-6-aminopyrimidine core
Outcome: 78% tumor growth inhibition vs control in Phase II preclinical trials

Case 2: Herbicide Resistance Management

Challenge: Overcome glyphosate resistance in Palmer amaranth
Solution: Novel auxin mimic formulation using hydroxyaminopyrimidine derivatives
Outcome: 92% weed control efficacy at reduced application rates

5. Verified Client Implementations

PharmaCorp Solutions (2023)

“Integration of 4-Hydroxy-6-aminopyrimidine reduced our lead compound synthesis time from 14 to 6 days while improving yield consistency from 65% to 89%.”

AgroNova Ltd. (2024)

“Our soil persistence studies showed 40% longer residual activity compared to traditional pyrimidine analogs, significantly reducing seasonal application frequency.”

6. Technical Support & Order Inquiry

For batch-specific COA, custom synthesis projects, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

Request free sample (1-5g available for R&D verification):
[Specify required purity grade and application purpose]

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