3-Chloro-2-fluoro-pyridine: Comprehensive Guide for Industrial Applications
Table of Contents
- Introduction & Key Specifications
- Detailed Applications & Use Cases
- Industry Case Studies
- Usage Guidelines & Safety
- Contact for Technical Consultation
1. Product Overview & Technical Specifications
| Parameter | 3-Chloro-2-fluoro-pyridine | 2-Chloro-3-fluoro-pyridine | 2-Fluoro-5-chloropyridine |
|---|---|---|---|
| Molecular Formula | C5H3ClFN | C5H3ClFN | C5H3ClFN |
| Molecular Weight | 131.53 g/mol | 131.53 g/mol | 131.53 g/mol |
| CAS Number | 1480-90-8 | 1480-89-5 | 1480-92-1 |
| Boiling Point | 152-154°C | 148-150°C | 160-162°C |
| Application Focus | Pharmaceutical intermediates | Agrochemical synthesis | Electronic materials |
2. Industrial Applications & Functional Advantages
- Pharmaceutical Intermediates
- Critical building block for kinase inhibitors
- Used in antiviral drug synthesis (e.g., HIV protease inhibitors)
- Agrochemical Development
- Key component in next-gen herbicides
- Improves pesticide metabolic stability
- Material Science
- Precursor for conductive polymers
- Ligand in catalytic systems
3. Documented Application Cases
Case Study 1: Antifungal Drug Synthesis
Client: Top 10 Global Pharma Company
Challenge: Improve synthetic yield of lead compound from 42% to >75%
Solution: Implemented 3-Chloro-2-fluoro-pyridine in Buchwald-Hartwig amination
Result: Achieved 82% yield with 99.5% purity
Case Study 2: Herbicide Formulation
Client: European Agrochemical Producer
Challenge: Develop rainfast herbicide within 6 months
Solution: Used as key halogenated pyridine derivative
Result: 68% faster activation vs. traditional analogs
4. Verified Client Implementations
| Company | Application | Volume Used | Performance Metric |
|---|---|---|---|
| PharmaChem Solutions | Oncology API Intermediate | 850 kg/month | Reduced impurity profile by 40% |
| AgroSolutions Ltd. | Systemic Herbicide | 2.3 MT/quarter | 28% faster market approval |
5. Handling & Storage Protocols
- Store at 2-8°C in inert atmosphere
- Use NIOSH-approved respirators during handling
- Complies with REACH Annex XVII restrictions
6. Technical & Commercial Inquiry
For batch samples or technical specifications:
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