Comprehensive Guide to 2,5-Dichloronicotinic Acid

Table of Contents

Product Overview

2,5-Dichloronicotinic Acid (CAS 6318-65-6) is a halogenated nicotinic acid derivative with molecular formula C₆H₃Cl₂NO₂. Key specifications include:

Parameter Value
Purity ≥98%
Appearance White to off-white crystalline powder
Melting Point 185-189°C
Solubility Soluble in DMSO, methanol; slightly soluble in water

Parameter Comparison

Compound Chlorine Positions Reactivity Pharma Applications
2,5-Dichloronicotinic Acid 2,5 Moderate Intermediate
2,3-Dichloronicotinic Acid 2,3 High Limited
2,6-Dichloronicotinic Acid 2,6 Low Agrochemicals

Detailed Applications

Pharmaceutical Intermediates

Used in synthesis of antipsychotic drugs and kinase inhibitors.

Agrochemical Production

Key precursor for chlorinated neonicotinoid insecticides.

Organic Synthesis

Building block for cross-coupling reactions in catalytic processes.

Usage Case Studies

Case 1: Antiviral Drug Intermediate

Pharma Company X achieved 22% yield improvement using our 2,5-Dichloronicotinic Acid in remdesivir analog synthesis.

Case 2: Herbicide Formulation

Agro Supplier Y developed 40% more stable pre-emergent herbicide using this compound as chelating agent.

Client Success Stories

ABC Pharmaceuticals (Germany)

Used 500kg batch for oncology drug intermediate, achieving 99.2% HPLC purity in final API.

XYZ Agrochemicals (USA)

Reduced synthesis steps from 7 to 4 in insecticide production using our optimized 2,5-Dichloronicotinic Acid.

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