2,4,6-Trichloro-5-methylpyrimidine

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2,4,6-Trichloro-5-methylpyrimidine Technical Guide

1. Product Specifications & Comparative Analysis

Parameter 2,4,6-Trichloro-5-methylpyrimidine Alternative Derivatives
CAS Number 1780-36-5 6554-69-4 (2,4,5-Trichloro-6-methylpyrimidine)
1780-42-3 (Isopropyl variant)
Molecular Formula C5H3Cl3N2 C7H7Cl3N2 (Isopropyl)
Molecular Weight 197.45 g/mol 196.46–227.43 g/mol (Derivatives)
Purity Grade ≥98% (Industrial/Research) 95–97% (Standard commercial grades)

Key Differentiation: The 2,4,6-trichloro substitution pattern with methyl at position 5 provides distinct reactivity in nucleophilic aromatic substitution reactions compared to positional isomers like 2,4,5-trichloro-6-methylpyrimidine.

2. Functional Applications

Core Industrial Uses

  • Agrochemical Synthesis: Intermediate for herbicides and fungicides targeting pyrimidine-dependent enzymes
  • Pharmaceutical Development: Building block for antiviral and anticancer drug candidates
  • Material Science: Precursor for functionalized polymers with halogen-rich backbones

Reaction Characteristics

  • Selective displacement of chlorine atoms under controlled conditions (temperature: 80–120°C)
  • Compatibility with Pd-catalyzed cross-coupling reactions
  • Stability in acidic environments (pH 2–6)

3. Operational Guidelines

Handling Protocols

  • Storage: Maintain at 2–8°C in sealed containers under inert atmosphere
  • Personal Protection: Class III chemical-resistant gloves, full-face respirator
  • Spill Management: Absorb with vermiculite, neutralize with 10% sodium bicarbonate

4. Industry Use Cases

Case A: Crop Protection Formulation

Used in 3-step synthesis of systemic fungicide with 92% yield improvement over previous intermediates

Case B: OLED Material Production

Key component in electron-transport layer materials achieving 15% efficiency enhancement

5. Client Success Stories

Client 1: European Pharma Research Consortium

  • Application: Antiviral prodrug development
  • Result: Achieved 99.2% regioselectivity in substitution reactions

Client 2: Asian Agrochemical Manufacturer

  • Application: Next-gen fungicide production
  • Result: Reduced synthesis steps from 5 to 2 with 40% cost savings

6. Request Customized Solutions

Contact our technical team for bulk pricing, custom synthesis, or regulatory documentation:

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