4-Methyl-2-nitropyridine

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4-Methyl-2-nitropyridine Product Guide

Table of Contents

Product Overview

4-Methyl-2-nitropyridine (CAS 4214-85-1) is a nitro-substituted pyridine derivative widely used in pharmaceutical synthesis and specialty chemical manufacturing. Key parameters:

Parameter Value
Molecular Formula C6H6N2O2
Molecular Weight 138.12 g/mol
Appearance Yellow crystalline powder
Purity ≥98% (HPLC)
Melting Point 54-58°C
Storage 2-8°C in amber glass containers

Technical Specifications & Comparative Analysis

Property 4-Methyl-2-nitropyridine 2-Nitropyridine 4-Nitropyridine
Reactivity Moderate electrophile High electrophile Low electrophile
Solubility Soluble in ethanol, acetone Water-miscible Limited solubility
Pharma Compatibility API intermediate Limited use Research-grade
Price/kg $320-400 $280-350 $450-600

Key Applications

Pharmaceutical Intermediates

Critical precursor for:

  • Antiviral drug candidates (e.g., HCV protease inhibitors)
  • Kinase inhibitor backbones
  • PET tracer synthesis

Agrochemical Synthesis

Used in developing:

  • Neonicotinoid alternatives
  • Herbicidal metabolites

Coordination Chemistry

Ligand for transition metal catalysts in:

  • Cross-coupling reactions
  • Asymmetric hydrogenation

Industry Use Cases

Case 1: Anticancer Drug Development

European biotech firm utilized 4-methyl-2-nitropyridine as key building block for third-generation PARP inhibitors, achieving 92% yield in Buchwald-Hartwig amination steps.

Case 2: OLED Materials

Japanese electronics manufacturer incorporated derivatives into electron-transport layers, enhancing device lifetime by 40% compared to standard materials.

Client Success Stories

Client A: PharmaCorp Ltd. (Germany)

  • Application: Synthesis of JAK2 inhibitors
  • Volume: 150 kg/year contract
  • Result: Reduced synthesis steps from 8 to 5

Client B: AgroScience Co. (USA)

  • Application: Novel fungicide development
  • Technical Support: Custom purity optimization (98.5% to 99.2%)
  • Outcome: 30% faster EPA approval timeline

Request Customized Solutions

Our technical team provides:

  • Bulk pricing (100kg+ orders)
  • GMP-grade synthesis
  • Custom derivatization services

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826

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