4-Methyl-2-nitropyridine Product Guide
Table of Contents
- Product Overview
- Technical Specifications & Comparative Analysis
- Key Applications
- Industry Use Cases
- Client Success Stories
- Request Customized Solutions
Product Overview
4-Methyl-2-nitropyridine (CAS 4214-85-1) is a nitro-substituted pyridine derivative widely used in pharmaceutical synthesis and specialty chemical manufacturing. Key parameters:
| Parameter | Value |
|---|---|
| Molecular Formula | C6H6N2O2 |
| Molecular Weight | 138.12 g/mol |
| Appearance | Yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 54-58°C |
| Storage | 2-8°C in amber glass containers |
Technical Specifications & Comparative Analysis
| Property | 4-Methyl-2-nitropyridine | 2-Nitropyridine | 4-Nitropyridine |
|---|---|---|---|
| Reactivity | Moderate electrophile | High electrophile | Low electrophile |
| Solubility | Soluble in ethanol, acetone | Water-miscible | Limited solubility |
| Pharma Compatibility | API intermediate | Limited use | Research-grade |
| Price/kg | $320-400 | $280-350 | $450-600 |
Key Applications
Pharmaceutical Intermediates
Critical precursor for:
- Antiviral drug candidates (e.g., HCV protease inhibitors)
- Kinase inhibitor backbones
- PET tracer synthesis
Agrochemical Synthesis
Used in developing:
- Neonicotinoid alternatives
- Herbicidal metabolites
Coordination Chemistry
Ligand for transition metal catalysts in:
- Cross-coupling reactions
- Asymmetric hydrogenation
Industry Use Cases
Case 1: Anticancer Drug Development
European biotech firm utilized 4-methyl-2-nitropyridine as key building block for third-generation PARP inhibitors, achieving 92% yield in Buchwald-Hartwig amination steps.
Case 2: OLED Materials
Japanese electronics manufacturer incorporated derivatives into electron-transport layers, enhancing device lifetime by 40% compared to standard materials.
Client Success Stories
Client A: PharmaCorp Ltd. (Germany)
- Application: Synthesis of JAK2 inhibitors
- Volume: 150 kg/year contract
- Result: Reduced synthesis steps from 8 to 5
Client B: AgroScience Co. (USA)
- Application: Novel fungicide development
- Technical Support: Custom purity optimization (98.5% to 99.2%)
- Outcome: 30% faster EPA approval timeline
Request Customized Solutions
Our technical team provides:
- Bulk pricing (100kg+ orders)
- GMP-grade synthesis
- Custom derivatization services
Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826


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