4-Methyl-2-nitropyridine (CAS 4214-85-1) is a nitro-substituted pyridine derivative widely used in pharmaceutical synthesis and specialty chemical manufacturing. Key parameters:
Parameter | Value |
---|---|
Molecular Formula | C6H6N2O2 |
Molecular Weight | 138.12 g/mol |
Appearance | Yellow crystalline powder |
Purity | ≥98% (HPLC) |
Melting Point | 54-58°C |
Storage | 2-8°C in amber glass containers |
Property | 4-Methyl-2-nitropyridine | 2-Nitropyridine | 4-Nitropyridine |
---|---|---|---|
Reactivity | Moderate electrophile | High electrophile | Low electrophile |
Solubility | Soluble in ethanol, acetone | Water-miscible | Limited solubility |
Pharma Compatibility | API intermediate | Limited use | Research-grade |
Price/kg | $320-400 | $280-350 | $450-600 |
Critical precursor for:
Used in developing:
Ligand for transition metal catalysts in:
European biotech firm utilized 4-methyl-2-nitropyridine as key building block for third-generation PARP inhibitors, achieving 92% yield in Buchwald-Hartwig amination steps.
Japanese electronics manufacturer incorporated derivatives into electron-transport layers, enhancing device lifetime by 40% compared to standard materials.
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