Methyl 5-chloropyrazine-2-carboxylate

Table of Contents

• Product Overview & Specifications
• Applications & Industrial Uses
• Usage Guidelines
• Case Studies
• Contact for Quotation

Methyl 5-chloropyrazine-2-carboxylate: Product Overview

Basic Specifications

Comparative Analysis

Key Applications

Pharmaceutical Intermediates

Critical precursor for antiviral agents and kinase inhibitors. Used in synthesis of:

• Anticancer drug candidates targeting EGFR pathways
• HIV protease inhibitors
• JAK-STAT signaling modulators

Agrochemical Synthesis

Essential building block for:

• Next-generation fungicides (e.g., pyrazine-based crop protectants)
• Herbicide metabolites
• Pesticide stabilizers

Material Science

• Coordination polymers for gas storage
• Ligand synthesis for catalytic systems

Operational Guidelines

Handling Protocol

1. Storage: Keep in sealed containers at 2-8°C under inert atmosphere
2. Solubility: Best in DMF (50mg/ml) or DCM (30mg/ml)
3. Reaction Conditions: Optimal at pH 6.5-7.5 in nucleophilic substitutions

Synthesis Example

Antiviral Compound Preparation:
1. Dissolve 5g in 100ml anhydrous THF
2. Add 1.2eq K₂CO₃ under N₂
3. React with 1.5eq aryl boronic acid at 60°C for 18h
4. Yield: 82-89% after column chromatography

Industry Case Studies

Case 1: European Pharma Company

Application: Synthesis of Phase III oncology drug
Usage: 45kg batch production
Results: 93% yield improvement vs previous intermediates

Case 2: Asian Agrochemical Manufacturer

Application: Novel fungicide development
Usage: 120kg/month
Results: 40% cost reduction in final API production

Case 3: US Research Institute

Application: MOF material development
Usage: 2kg pilot study
Results: Achieved record 18.5% porosity in coordination polymer

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