1. Product Overview & Specifications

Fmoc-L-Glutamic Acid 1-tert-Butyl Ester (CAS 84793-07-7) is a protected amino acid derivative widely used in peptide synthesis. Its molecular formula is C₂₄H₂₇NO₆, with a molecular weight of 425.47 g/mol.

Key Specifications:

Supplier Comparison:

2. Key Applications

This compound serves as a critical building block in:

• Peptide Drug Synthesis: Used in the production of liraglutide (anti-diabetic), thymosin alpha-1 (immunotherapy), and other therapeutic peptides.
• Research Applications: Enables selective protection of glutamic acid during solid-phase peptide synthesis (SPPS).
• Chemical Modifications: Facilitates controlled γ-carboxyl group activation in complex organic reactions.

3. Usage Guidelines

Synthesis Protocol:

1. React L-Glutamic Acid 1-tert-butyl ester with Fmoc-OSu (9-fluorenylmethyl succinimidyl carbonate) in anhydrous DMF.
2. Maintain pH 8–9 using N,N-diisopropylethylamine (DIPEA) at 0–5°C.
3. Purify via column chromatography (86% yield typical).

Handling Precautions:

• Use PPE (gloves, goggles) to prevent skin/eye contact.
• Store under inert gas (argon/nitrogen) for long-term stability.
• Avoid incompatible reagents: strong oxidizers, acids/bases.

4. Case Studies

Case 1: Liraglutide Production (Hubei Yuanyang Bio)

Application: Key intermediate in GLP-1 analog synthesis
Scale: 50kg batch production
Outcome: Achieved 92% coupling efficiency in SPPS cycles.

Case 2: Thymosin α-1 Development (Jiangsu Jitai Peptide)

Application: γ-carboxyl protection in immunotherapeutic peptide
Scale: 10g research batches
Outcome: Reduced side reactions by 40% compared to Boc-protected analogs.

Case 3: Neurological Peptide Research (Shanghai Acmec)

Application: Blood-brain barrier targeting peptide design
Scale: 5mg–1g laboratory use
Outcome: Enabled precise γ-site functionalization for receptor targeting.

5. Contact for Inquiries

For technical specifications, bulk pricing, or custom synthesis requirements: