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Specialized inFmoc-L-Glutamic acid 1-tert-butyl ester CAS 84793-07-7and related product development and production

Chemical Name: Fmoc-L-Glutamic acid 1-tert-butyl ester
CAS No.: 84793-07-7
Molecular Fomula: C10H9BO2
Molecular weight:  171.99
Appearance:  white powder
Assay: ≥99.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Comprehensive Guide to Fmoc-L-Glutamic Acid 1-tert-Butyl Ester (CAS 84793-07-7)

Table of Contents

1. Product Overview & Specifications

Fmoc-L-Glutamic Acid 1-tert-Butyl Ester (CAS 84793-07-7) is a protected amino acid derivative widely used in peptide synthesis. Its molecular formula is C24H27NO6, with a molecular weight of 425.47 g/mol.

Key Specifications:

Parameter Value
Appearance White to off-white crystalline powder
Purity 97%–99% (HPLC)
Melting Point 78–80°C
Storage 2–8°C, protected from light and moisture

Supplier Comparison:

Supplier Purity Packaging Price Range
Acmec 97% 5g, 10g $158–$308
Hubei Yuanyang Bio 99% 25kg/drum $6,120/kg
Jiangsu Jitai Peptide 99% 10g, 50g $100–$500

2. Key Applications

This compound serves as a critical building block in:

  • Peptide Drug Synthesis: Used in the production of liraglutide (anti-diabetic), thymosin alpha-1 (immunotherapy), and other therapeutic peptides.
  • Research Applications: Enables selective protection of glutamic acid during solid-phase peptide synthesis (SPPS).
  • Chemical Modifications: Facilitates controlled γ-carboxyl group activation in complex organic reactions.

3. Usage Guidelines

Synthesis Protocol:

  1. React L-Glutamic Acid 1-tert-butyl ester with Fmoc-OSu (9-fluorenylmethyl succinimidyl carbonate) in anhydrous DMF.
  2. Maintain pH 8–9 using N,N-diisopropylethylamine (DIPEA) at 0–5°C.
  3. Purify via column chromatography (86% yield typical).

Handling Precautions:

  • Use PPE (gloves, goggles) to prevent skin/eye contact.
  • Store under inert gas (argon/nitrogen) for long-term stability.
  • Avoid incompatible reagents: strong oxidizers, acids/bases.

4. Case Studies

Case 1: Liraglutide Production (Hubei Yuanyang Bio)

Application: Key intermediate in GLP-1 analog synthesis
Scale: 50kg batch production
Outcome: Achieved 92% coupling efficiency in SPPS cycles.

Case 2: Thymosin α-1 Development (Jiangsu Jitai Peptide)

Application: γ-carboxyl protection in immunotherapeutic peptide
Scale: 10g research batches
Outcome: Reduced side reactions by 40% compared to Boc-protected analogs.

Case 3: Neurological Peptide Research (Shanghai Acmec)

Application: Blood-brain barrier targeting peptide design
Scale: 5mg–1g laboratory use
Outcome: Enabled precise γ-site functionalization for receptor targeting.

5. Contact for Inquiries

For technical specifications, bulk pricing, or custom synthesis requirements:

Contact Method Details
Email info@vivalr.com
Phone (86) 15866781826

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Technical direction

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Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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