4-Amino-3-fluoropyridine: Comprehensive Guide for Industrial Applications
Table of Contents
1. Product Overview and Specifications
4-Amino-3-fluoropyridine (CAS 67515-47-1) is a fluorinated pyridine derivative with molecular formula C5H5FN2. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥99.5% | 98.0-99.0% | 97.5-98.5% |
| Melting Point | 128-132°C | 125-130°C | 120-128°C |
| Solubility | Methanol, DCM | Limited in DCM | Ethanol only |
2. Key Applications and Industrial Uses
This specialty chemical serves critical roles in:
- Pharmaceutical Intermediates: Synthesis of kinase inhibitors and antiviral agents
- Agrochemicals: Building block for next-generation herbicides
- Electronics: Precursor for OLED charge-transport materials
3. Step-by-Step Usage Guidelines
- Storage: Maintain at 2-8°C in airtight containers
- Handling: Use nitrogen atmosphere for moisture-sensitive reactions
- Reaction Optimization: Recommended molar ratio 1:1.2 with carbonyl compounds
4. Real-World Case Studies
Case 1: Pharmaceutical Development
Client: Top 10 Global Pharma Company
Application: Synthesis of Bruton’s tyrosine kinase (BTK) inhibitor
Result: 23% yield improvement vs. traditional amination methods
Case 2: Agricultural Innovation
Client: EU-Based Agrochemical Leader
Application: Novel sulfonylurea herbicide development
Result: Achieved 98.7% purity in final API
5. Technical Comparison with Alternatives
| Property | 4-Amino-3-fluoropyridine | 3-Fluoro-4-nitropyridine | 4-Chloro-aminopyridine |
|---|---|---|---|
| Reactivity | High | Moderate | Low |
| Shelf Life | 24 months | 18 months | 12 months |
6. Request Customized Solutions
Our technical team provides:
- Bulk quantities (100kg+ batches)
- Custom fluorination services
- Regulatory support (REACH, FDA DMF)
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