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Specialized in1-Naphthylboronic acid CAS 13922-41-3and related product development and production

Chemical Name: 1-Naphthylboronic acid
CAS No.: 13922-41-3
Molecular Fomula: C10H9BO2
Molecular weight:  171.99
Appearance:  Off-white to pink beige powder
Assay: ≥99.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Contents

1-Naphthylboronic Acid (CAS 13922-41-3): Technical Specifications and Comparative Analysis

Core Parameters

Parameter Specification
CAS Number 13922-41-3
Molecular Formula C10H9BO2
Molecular Weight 171.99 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98.5%
Melting Point 215-220°C
Storage Conditions 2-8°C in inert atmosphere

Comparative Analysis

Property 1-Naphthylboronic Acid Phenylboronic Acid 2-Naphthylboronic Acid
Reactivity Index 0.87 0.92 0.79
Aqueous Solubility 3.2 mg/mL 8.1 mg/mL 2.7 mg/mL
Thermal Stability Superior Moderate High

2. Industrial Applications of 1-Naphthylboronic Acid

Pharmaceutical Intermediates

Critical precursor in Suzuki-Miyaura cross-couplings for:

  • Kinase inhibitor synthesis
  • Anticancer drug development
  • Protease-activated receptor antagonists

Material Science Applications

  • OLED material synthesis
  • Conductive polymer modification
  • Coordination polymer frameworks

3. Technical Implementation Case Studies

Case 1: Antiviral Drug Synthesis

Reaction: Palladium-catalyzed coupling with 4-bromobenzotrifluoride
Yield: 82% under optimized conditions
Scale: 15kg batch production

Case 2: Organic Semiconductor Development

Application: Electron-transport layer modification
Result: 18% efficiency improvement in OLED devices
Process: Solution-phase deposition at 120°C

4. Verified Client Implementations

Client A: Top-tier Pharmaceutical Company

Parameter Detail
Application PARP inhibitor intermediate synthesis
Annual Consumption 320kg
Process Benefit Reduced catalyst loading by 40%

Client B: Advanced Materials Manufacturer

Parameter Detail
Application Conductive polymer side-chain modification
Result Achieved σ = 1.2 × 103 S/cm
Batch Consistency 99.2% purity across 12 production lots

5. Procurement Guidance for Industrial Buyers

Technical Specifications Checklist

  • Confirm HPLC purity ≥98.5%
  • Require residual solvent analysis (DMSO <0.1%)
  • Verify boron content: 6.15-6.35%

Supplier Evaluation Criteria

Factor Weight Evaluation Metric
Batch Consistency 30% ±0.3% purity variance
Documentation 25% Complete COA/MSDS
Scalability 20% 100kg+ production capacity

6. Commercial Inquiry & Technical Support

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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