3,5-Dibromo-2-pyridylamine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
3,5-Dibromo-2-pyridylamine (CAS 100486-85-5) is a brominated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C5H4Br2N2 |
| Molecular Weight | 275.91 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
Comparative Analysis
| Compound | Reactivity | Solubility |
|---|---|---|
| 3,5-Dibromo-2-pyridylamine | High (Br groups enable cross-coupling) | Soluble in DMF, DMSO |
| 2-Amino-5-bromopyridine | Moderate | Limited solubility |
2. Applications & Use Cases
Pharmaceutical Intermediates
Used in Suzuki-Miyaura reactions to synthesize kinase inhibitors and antiviral agents.
Agrochemical Synthesis
Key precursor for herbicides and fungicides due to its halogen reactivity.
Material Science
Building block for metal-organic frameworks (MOFs) and conductive polymers.
3. Step-by-Step Usage Guidelines
- Handling: Use PPE (gloves, goggles) in a fume hood.
- Storage: Keep at 2-8°C in airtight containers.
- Reaction Example: Mix 1g with Pd(PPh3)4 in THF under N2 for cross-coupling.
4. Customer Case Studies
Case 1: PharmaTech Solutions
Application: Synthesized a Bruton’s tyrosine kinase (BTK) inhibitor.
Result: Achieved 92% yield in Buchwald-Hartwig amination.
Case 2: AgroChem Ltd.
Application: Developed a novel triazole fungicide.
Result: Reduced synthesis steps from 5 to 3 using bromine-directed coupling.
5. Contact for Inquiries
Request custom synthesis or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826
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