2-Cyano-3-chloropyridine

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2-Cyano-3-chloropyridine: Technical Guide for Industrial Applications

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 2-Cyano-3-chloropyridine 3-Chloropyridine 2-Cyanopyridine
CAS Number 33252-27-6 626-60-8 1452-81-3
Molecular Formula C6H3ClN2 C5H4ClN C6H4N2
Boiling Point 285-287°C 148-150°C 265°C
Reactivity Index High (dual functional groups) Moderate Moderate

2. Industrial Applications & Functional Mechanisms

This heterocyclic compound serves as critical building block in:

  • Pharmaceutical intermediates for kinase inhibitors
  • Agrochemical precursors for systemic herbicides
  • Coordination chemistry for catalytic systems
  • Cross-coupling reactions in specialty chemicals

3. Operational Protocols & Safety Guidelines

Recommended handling parameters:

  • Storage: Nitrogen atmosphere, below 25°C
  • Reaction solvent compatibility: DMF, THF, Acetonitrile
  • Incompatible materials: Strong oxidizers, metallic sodium
  • Personal protection: Chemically resistant gloves + full-face respirator

4. Pharmaceutical Application Case Study

Client: European API Manufacturer (Confidential)

  • Application: Key intermediate for JAK3 inhibitor production
  • Scale: 800kg/month continuous process
  • Yield improvement: 72% → 89% after process optimization
  • Purity requirement: >99.7% (HPLC)

5. Agrochemical Formulation Case

Client: Southeast Asia Crop Protection Company

  • End product: Chloropyrifos alternative formulation
  • Batch size: 12MT per synthesis campaign
  • Cost reduction: 23% through improved cyano group stability
  • Regulatory compliance: Achieved EPA & EU REACH standards

6. Technical Support & Custom Synthesis

Contact our chemists for tailored solutions:

Email: info@vivalr.com
Tel: (86) 15866781826

Services include:

  • Custom purity grades (Industrial >98%, Pharma >99.5%)
  • Bulk packaging options (25kg drums to 1MT containers)
  • Regulatory documentation support
  • Joint process development programs
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