2-Methoxy-3-chloro-5-bromopyridine: Technical Guide & Industry Applications
Table of Contents
- Product Overview & Specifications
- Key Parameters Comparison
- Industrial Applications & Use Cases
- Synthesis Process & Handling Protocols
- Verified Customer Implementations
- Supplier Inquiry & Technical Support
1. Product Overview & Specifications
Chemical Name: 2-Methoxy-3-chloro-5-bromopyridine
CAS No.: 944401-71-4
Molecular Formula: C₆H₄BrClNO
Molecular Weight: 236.46 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Storage: 2-8°C in inert atmosphere
2. Key Parameters Comparison
| Parameter | 2-Methoxy-3-chloro-5-bromopyridine | 3-Bromo-5-chloropyridine | 2-Methoxy-5-bromopyridine |
|---|---|---|---|
| Reactivity in Cross-Coupling | High (Buchwald-Hartwig/Suzuki) | Moderate | Low |
| Thermal Stability | Stable up to 150°C | Decomposes at 120°C | Stable up to 180°C |
| Pharmaceutical Intermediate Usage | FDA-approved drug syntheses | Research-stage compounds | Limited applications |
3. Industrial Applications & Use Cases
3.1 Pharmaceutical Intermediate
Critical component in synthesis of:
- Kinase inhibitors (e.g., Bruton’s tyrosine kinase (BTK) inhibitors)
- Antiviral agents targeting RNA polymerases
- Oncology drugs with PI3Kδ inhibition properties
3.2 Agrochemical Synthesis
Key building block for:
- Neonicotinoid replacements with reduced environmental impact
- Fungicides with systemic action
4. Synthesis Process & Handling Protocols
4.1 Manufacturing Workflow
- Chlorination of 2-methoxypyridine (0-5°C, Cl₂ gas)
- Bromination using NBS (AIBN catalyst, 80°C)
- Crystallization purification (ethanol/water system)
4.2 Safety Protocols
| Parameter | Specification |
|---|---|
| Flash Point | >200°C (closed cup) |
| LD50 (Oral Rat) | >2000 mg/kg |
5. Verified Customer Implementations
Case 1: Top 10 Pharma Company (Anti-Cancer Drug Development)
Application: Synthesis of third-generation BTK inhibitor
Scale: 150kg batch production
Yield Improvement: 68% → 82% after process optimization
Technical Support: Customized bromination control protocols
Case 2: EU Agrochemical Manufacturer
Application: Novel insecticide for resistant pest strains
Regulatory Compliance: Achieved REACH certification in 8 months
Purity Requirement: 99.5% for GLP toxicity studies
6. Supplier Inquiry & Technical Support
For technical specifications sheets or custom synthesis requirements:
Email: info@vivalr.com
Phone: (86) 15866781826
相关产品
Chemical Name: 3-Hydroxybutyric acid
CAS No.: 625-71-8
Molecular Formula: C4H8O3
Molecular Weight: 104.1
Appearance: White powder
Chemical Name: N-(3-Aminopropyl)morpholine
CAS No.: 123-00-2
Molecular Formula: C7H16N2O
Molecular Weight: 144.21
Appearance: Colorless transparent liquid
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: 1,1,2,2-Tetrachloroethane
Other Name: Tetrachlorethane
CAS No.: 79-34-5
Molecular Formula: C2H2Cl4
Molecular Weight: 167.85
Appearance: Liquid
Chemical Name: Di-n-amyl disulfide
Cas No.: 112-51-6
Molecular Fomula: C10H22S2
Molecular Weight: 206.41
Chemical Name: Ammonium Iron(II) Sulfate
Synonyms: Diammonium iron bis(sulphate); iron (ii) ammonium sulfate
CAS No.: 10045-89-3
Molecular Formula: FeH5NO4S
Molecular Weight: 170.95
Chemical Name: Eicosatetraynoic acid(ETYA)
Cas No.: 1191-85-1
Molecular Fomula: C20H24O2
Molecular Weight: 296.4
Chemical Name: 4-((2-Furylmethyl)thio)-4-methylpentan-2-one
Cas No.: 64835-96-7
Molecular Fomula: C11H16O2S
Molecular Weight: 212.31
Appearance: Colorless to light yellow liquid
Chemical Name: Ethyl Hexanoate
Synonyms: Ethyl caproate; Caproic acid ethyl ester; Ethyl butyl acetate; capronic ether; hexanoic acid ethyl ester
CAS No.: 123-66-0
Molecular Formula: C8H16O2
Molecular Weight: 144.21
Chemical Name: Potassium Castorate
CAS No.: 8013-05-6
Molecular Formula: C57H107K3O12
Molecular Weight: 1101.74718
Appearance: Yellow Liquid
Chemical Name: Tribehenin
Cas No.: 18641-57-1
Molecular Fomula: C69H134O6
Molecular Weight: 1059.8
Appearance: White waxy powder or solid
评论
目前还没有评论。