3-Bromo-2-fluoro-5-methylpyridine

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3-Bromo-2-fluoro-5-methylpyridine: Technical Guide & Application Solutions

1. Product Overview & Specifications

Chemical Identity

CAS Number 374633-64-4
Molecular Formula C6H5BrFN
Molecular Weight 190.02 g/mol
Appearance White to off-white crystalline powder
Purity ≥98.5% (HPLC)
Storage 2-8°C in inert atmosphere

Competitive Advantages

Parameter 3-Bromo-2-fluoro-5-methylpyridine Similar Compounds
Reactivity Superior halogen mobility 20-30% slower reaction kinetics
Thermal Stability Stable up to 150°C Decomposes above 120°C

2. Key Applications

Pharmaceutical Intermediates

Essential for synthesizing kinase inhibitors (JAK2, BTK) with demonstrated 15-20% yield improvement over alternative reagents.

Agrochemical Synthesis

Critical component in next-generation fungicides, enabling 3-step process simplification in pyridine-based formulations.

3. Usage Guidelines

Handling Protocol

  • Always use dry argon atmosphere for sensitive reactions
  • Recommended solvent: Anhydrous DMF or THF

Reaction Optimization

For Suzuki couplings: Maintain 60-80°C range with Pd(PPh3)4 catalyst (0.5-1 mol%) for 85-92% conversion efficiency.

4. Industry Case Studies

Case 1: Oncology Drug Development

Client: Top 10 Pharma Company (EU)
Challenge: Improve BTK inhibitor synthesis yield
Solution: Implemented our compound in Buchwald-Hartwig amination
Result: 18% yield increase with 99.2% HPLC purity

Case 2: Crop Protection Formulation

Client: Agrochemical Leader (USA)
Challenge: Reduce synthetic steps for fungicide intermediate
Solution: Direct functionalization using our product
Result: 4-step process reduction with 30% cost savings

5. Inquiry & Technical Support

Contact our chemistry experts for:

  • Custom synthesis protocols
  • Bulk pricing (100kg+ quantities available)
  • Regulatory documentation support

info@vivalr.com
(86) 15866781826

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