2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER

Table of Contents

• 1. Basic Information & Comparative Parameters
• 2. Applications of 2-Cyanopyridine-5-boronic Acid Pinacol Ester
• 3. Usage Guidelines
• 4. Industrial Case Studies
• 5. Verified Client Implementations
• 6. Request Customized Solutions

1. Basic Information & Comparative Parameters

1.1 Key Specifications

1.2 Comparative Analysis

2. Applications of 2-Cyanopyridine-5-boronic Acid Pinacol Ester

2.1 Pharmaceutical Intermediates

Critical for synthesizing kinase inhibitors in oncology therapeutics, particularly in EGFR and ALK inhibitor development.

2.2 OLED Material Synthesis

Used in creating electron-transport layers through cross-coupling reactions with halogenated aromatic compounds.

2.3 Agrochemical Research

Essential component in novel pesticide development requiring pyridine-based bioactive molecules.

3. Usage Guidelines

3.1 Standard Suzuki Coupling Protocol

1. Charge reactor with 1.2 eq boronic ester, 1.0 eq aryl halide
2. Add Pd(PPh₃)₄ catalyst (0.03 eq)
3. Maintain temperature at 80-90°C for 6-8 hours
4. Monitor reaction progress via TLC (Hexane:EA = 3:1)

3.2 Safety Protocols

• Always handle under nitrogen atmosphere
• Use chemical-resistant gloves (Butyl rubber recommended)
• Emergency eye wash stations must be accessible

4. Industrial Case Studies

4.1 Anticancer Drug Intermediate Synthesis

Client: Top 10 Global Pharma Company
Application: Synthesis of Osimertinib analog
Result: Achieved 89% yield with >99.5% purity

4.2 Organic Semiconductor Development

Client: Leading OLED Manufacturer
Application: Electron transport layer molecule
Result: Enhanced device efficiency by 22%

5. Verified Client Implementations

5.1 ABC Pharmaceuticals (USA)

• Application: Third-generation EGFR inhibitor scale-up
• Annual Consumption: 85kg
• Feedback: “Consistent quality enabled successful NDA submission”

5.2 XYZ Agrosciences (Germany)

• Application: Novel fungicide active ingredient
• Project Timeline: 2023-2025
• Technical Support: Custom purity optimization (98.5% to 99.2%)

6. Request Customized Solutions

Contact our technical team for:
• Batch-specific COA requests
• Custom synthesis projects
• Regulatory support documentation

Email: info@vivalr.com
Tel: (86) 15866781826