2-Chloro-4-iodopyridine-3-carboxaldehyde

2-Chloro-4-iodopyridine-3-carboxaldehyde: Comprehensive Guide for Buyers & Researchers

Technical Specifications & Comparative Analysis

Industrial Applications & Functional Insights

Core Functional Groups:

• Iodo Substituent: Enables cross-coupling reactions (Suzuki, Buchwald-Hartwig)
• Aldehyde Group: Facilitates condensation reactions
• Chlorine Atom: Enhances electronic properties for material science applications

Key Application Sectors:

1. Pharmaceutical Intermediates:
   • Kinase inhibitor development
   • Anticancer compound synthesis
2. Agrochemical Research:
   • Herbicide precursors
   • Fungicidal compounds
3. Material Science:
   • Coordination polymers
   • OLED precursor molecules

Pharmaceutical Research Case Study

Client Profile:

• European Oncology Research Center
• Project: Targeted cancer therapy development

Application Details:

Used as key intermediate in synthesizing PI3Kδ inhibitors. The iodo group enabled efficient Buchwald-Hartwig amination at position 4, while the aldehyde facilitated subsequent Knoevenagel condensation to create bioactive heterocycles.

Agrochemical Development Application

Client Profile:

• Asian Agrochemical Manufacturer
• Project: Next-gen fungicide formulation

Technical Implementation:

The compound served as central building block in creating triazolopyridine derivatives through copper-mediated cyclization. Demonstrated 83% efficacy against Magnaporthe oryzae in rice blast disease models.

Strategic Procurement Guidance

Quality Verification Protocols:

1. Require batch-specific:
   • HPLC chromatograms
   • NMR spectra
   • Residual solvent analysis
2. Storage & Handling:
   • Store at 2-8°C under inert atmosphere
   • Maximum shelf life: 24 months

Expert Consultation & Sample Requests

Contact our technical team for:

• Custom synthesis options
• Bulk pricing (10kg+ quantities)
• Regulatory documentation support

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