Table of Contents
- Product Overview
- Specifications & Comparative Analysis
- Applications
- Usage Guidelines
- Case Studies
- Contact for Technical Support
Methyl Tetrahydropyran-4-Carboxylate Overview
CAS No.: 942195-03-1
Molecular Formula: C8H12O3
Molecular Weight: 156.18 g/mol
Methyl tetrahydropyran-4-carboxylate is a high-purity ester derivative widely used as a versatile intermediate in pharmaceuticals, agrochemicals, and specialty chemical synthesis. Its tetrahydropyran ring structure enhances stability and reactivity in nucleophilic reactions.
Specifications & Comparative Analysis
| Parameter | Methyl THP-4-Carboxylate | Ethyl THP-4-Carboxylate | THP-Protecting Group Reagents |
|---|---|---|---|
| Purity | ≥98% (HPLC) | ≥95% | 90-99% |
| Boiling Point | 215-217°C | 228-230°C | Varies by product |
| Solubility | Miscible in DCM, THF, ethanol | Limited in polar solvents | Dependent on functional groups |
| Typical Applications | API intermediates, chiral synthesis | Bulk chemical production | Protecting-group strategies |
Key Applications
Pharmaceutical Industry
- Intermediate for antiviral drugs (e.g., protease inhibitors)
- Chiral building block in CNS drug development
Agrochemicals
- Synthesis of herbicidal compounds
- Stabilizer in pesticide formulations
Usage Guidelines
Laboratory Scale
- Recommended storage: 2-8°C under inert gas
- Use anhydrous conditions for coupling reactions
Industrial Scale
- Batch reactor compatibility: Glass-lined or Hastelloy
- Optimal reaction temperature range: 40-80°C
Case Studies
Case 1: Antiviral Drug Intermediate Synthesis
Client: Top 10 Global Pharma Company (Confidential)
Application: Used in 3-step synthesis of Remdesivir analogue
Result: 22% yield improvement vs. previous intermediates
Case 2: Chiral Catalyst Development
Client: University of Cambridge Research Group
Application: Key component in asymmetric hydrogenation catalysts
Result: Achieved 95% enantiomeric excess (ee)
Technical & Commercial Inquiry
Request custom synthesis protocols or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
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