Parameter | 2-Chloro-4-iodopyridine-3-carboxaldehyde | Similar Compound A | Similar Compound B |
---|---|---|---|
CAS Number | 1268805-85-7 | XXXXXX-XX-X | XXXXXX-XX-X |
Molecular Formula | C6H3ClINO | C6H4ClNO | C7H5FIO |
Purity Grade | ≥98% (HPLC) | ≥95% | ≥97% |
Reactivity Index | High (Iodo Group) | Moderate | Low |
Used as key intermediate in synthesizing PI3Kδ inhibitors. The iodo group enabled efficient Buchwald-Hartwig amination at position 4, while the aldehyde facilitated subsequent Knoevenagel condensation to create bioactive heterocycles.
The compound served as central building block in creating triazolopyridine derivatives through copper-mediated cyclization. Demonstrated 83% efficacy against Magnaporthe oryzae in rice blast disease models.
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