6-Amino-2-hydroxypyridine: Technical Guide & Applications
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 6-Amino-2-hydroxypyridine | Analogous Compounds |
|---|---|---|
| CAS Number | 5154-00-7 | 38767-72-5 (4-Amino-2-hydroxypyridine) 59315-44-5 (3-Amino-2-hydroxypyridine) |
| Molecular Formula | C5H6N2O | C5H6N2O (Isomeric variations) |
| Molecular Weight | 110.11 g/mol | 110.11 g/mol (Structural isomers) |
| Stability | Light-sensitive | Varies by substitution pattern |
2. Key Applications & Functional Properties
This heterocyclic compound serves critical roles in:
- Pharmaceutical Intermediates: Synthesis of bioactive molecules through regioselective reactions
- Coordination Chemistry: Ligand formation with transition metals for catalytic systems
- Agrochemical Development: Building block for pesticide metabolites
- Material Science: Precursor for conductive polymers and OLED components
3. Operational Guidelines & Best Practices
Storage: Maintain in amber glass at 2-8°C under inert atmosphere
Handling: Use nitrogen-purged reactors for amino-group protection reactions
Reactivity Profile:
- Participates in Buchwald-Hartwig amination
- Undergoes palladium-catalyzed cross-coupling
- pH-dependent solubility (pKa ~4.2)
4. Industry Case Studies
Case 1: Antiviral Drug Synthesis
Used as nucleoside analog precursor in HCV protease inhibitor development
Case 2: Metal-Organic Frameworks
Enabled creation of Cu(II)-based MOFs with 89% porosity enhancement
5. Client Success Stories
PharmaTech Solutions
Achieved 32% yield improvement in kinase inhibitor synthesis through optimized coupling protocols
Advanced Materials Co.
Developed corrosion-resistant coatings using nickel coordination complexes
6. Technical Consultation & Inquiry
For batch-specific COA, custom synthesis, or technical support:
Email: info@vivalr.com
Tel: (86) 15866781826
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