2,5-Dibromopyrimidine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Basic Information
2,5-Dibromopyrimidine (CAS 10277-87-3) is a brominated heterocyclic compound widely used in pharmaceutical and material science research. Key parameters:
| Parameter | Value |
|---|---|
| Molecular Formula | C₄H₂Br₂N₂ |
| Molecular Weight | 277.88 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Storage | 2-8°C in airtight container |
Comparative Analysis
| Feature | 2,5-Dibromopyrimidine | 2,4-Dibromopyrimidine | 5-Bromopyrimidine |
|---|---|---|---|
| Reactivity | High (dual bromine sites) | Moderate | Low |
| Pharma Applications | Kinase inhibitor synthesis | Antiviral agents | Intermediate |
| Price (per gram) | $220 | $180 | $95 |
2. Key Applications & Use Cases
Pharmaceutical Intermediates
Used in synthesis of:
- EGFR tyrosine kinase inhibitors
- Anticancer drug candidates
- Antiviral compounds
Material Science
- OLED material precursors
- Coordination polymers
3. Industry-Specific Case Studies
Case 1: Oncology Drug Development
Challenge: Low yield in kinase inhibitor synthesis (42%).
Solution: Optimized coupling reaction using 2,5-dibromopyrimidine.
Result: Yield increased to 78% with 99.2% purity.
Case 2: Flexible OLED Production
Challenge: Inconsistent electron transport layer performance.
Solution: Incorporated 2,5-dibromopyrimidine-derived monomer.
Result: 22% improvement in device efficiency.
4. Client Success Stories
European Pharma Leader
Developed third-generation EGFR inhibitors using our GMP-grade 2,5-dibromopyrimidine, reducing synthesis steps from 14 to 9.
Asian Materials Innovator
Created patent-pending OLED materials with enhanced thermal stability (Td = 315°C) through bromine substitution chemistry.
5. Contact for Custom Solutions
Request technical specifications or discuss bulk orders:
info@vivalr.com
(86) 15866781826
Available forms: Powder, solution (DMSO/THF), custom derivatives.
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