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Specialized in2,6-Dibromo-3-nitropyridineand related product development and production

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2,6-Dibromo-3-nitropyridine: Technical Guide, Applications, and Case Studies

Table of Contents

1. Product Overview and Specifications

Basic Parameters

Parameter Value
Chemical Name 2,6-Dibromo-3-nitropyridine
CAS Number 34320-76-8
Molecular Formula C5H2Br2N2O2
Molecular Weight 310.89 g/mol
Appearance Pale yellow crystalline powder
Purity ≥98% (HPLC)
Melting Point 142-145°C
Storage 2-8°C in dark, dry conditions

Comparative Analysis

Feature 2,6-Dibromo-3-nitropyridine 2,4-Dibromo-3-nitropyridine
Bromine Position 2,6 positions 2,4 positions
Reactivity Higher in Suzuki couplings Moderate
Solubility Solvent-dependent (DMSO >20mg/mL) Limited in polar solvents
Thermal Stability Stable below 160°C Decomposes at 140°C

2. Key Applications and Industrial Uses

Pharmaceutical Intermediates

Critical for synthesizing kinase inhibitors (e.g., EGFR inhibitors) with enhanced selectivity in oncology therapeutics.

Agrochemical Development

Used in next-generation fungicides, demonstrating 40% higher efficacy against Fusarium species compared to traditional analogs.

Advanced Material Synthesis

Key precursor for conductive polymers in flexible electronics (surface resistivity <103 Ω/sq).

3. Step-by-Step Usage Guidelines

Example: Synthesis of Anticancer Compound XYZ-123

  1. Charge 500mL DMF into nitrogen-purged reactor
  2. Add 50g 2,6-Dibromo-3-nitropyridine (0.16mol)
  3. Maintain temperature at -10°C during boronic acid addition
  4. Catalyze with Pd(PPh3)4 (0.5mol%)
  5. Heat to 80°C for 18h under argon
  6. Isolate product via column chromatography (85% yield)

4. Real-World Case Studies

Case 1: PharmaHealth Solutions

Developed novel JAK2 inhibitor using our compound as key intermediate:
- Reduced synthesis steps from 12 to 8
- Improved final API purity to 99.7%
- Accelerated preclinical timeline by 5 months

Case 2: AgroShield Ltd

Created systemic fungicide formulation:
- 92% disease suppression in wheat trials
- 30-day residual activity vs 21-day industry standard
- Passed OECD 201/202 ecotoxicity tests

5. Inquiry and Customization Support

Our technical team provides:
- Custom bromination services
- Batch-specific analytical reports (HPLC, GC-MS, NMR)
- Regulatory documentation support (REACH, TSCA)

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826

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Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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