2,6-Dibromo-3-nitropyridine

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2,6-Dibromo-3-nitropyridine: Technical Guide, Applications, and Case Studies

1. Product Overview and Specifications

Basic Parameters

Parameter Value
Chemical Name 2,6-Dibromo-3-nitropyridine
CAS Number 34320-76-8
Molecular Formula C5H2Br2N2O2
Molecular Weight 310.89 g/mol
Appearance Pale yellow crystalline powder
Purity ≥98% (HPLC)
Melting Point 142-145°C
Storage 2-8°C in dark, dry conditions

Comparative Analysis

Feature 2,6-Dibromo-3-nitropyridine 2,4-Dibromo-3-nitropyridine
Bromine Position 2,6 positions 2,4 positions
Reactivity Higher in Suzuki couplings Moderate
Solubility Solvent-dependent (DMSO >20mg/mL) Limited in polar solvents
Thermal Stability Stable below 160°C Decomposes at 140°C

2. Key Applications and Industrial Uses

Pharmaceutical Intermediates

Critical for synthesizing kinase inhibitors (e.g., EGFR inhibitors) with enhanced selectivity in oncology therapeutics.

Agrochemical Development

Used in next-generation fungicides, demonstrating 40% higher efficacy against Fusarium species compared to traditional analogs.

Advanced Material Synthesis

Key precursor for conductive polymers in flexible electronics (surface resistivity <103 Ω/sq).

3. Step-by-Step Usage Guidelines

Example: Synthesis of Anticancer Compound XYZ-123

  1. Charge 500mL DMF into nitrogen-purged reactor
  2. Add 50g 2,6-Dibromo-3-nitropyridine (0.16mol)
  3. Maintain temperature at -10°C during boronic acid addition
  4. Catalyze with Pd(PPh3)4 (0.5mol%)
  5. Heat to 80°C for 18h under argon
  6. Isolate product via column chromatography (85% yield)

4. Real-World Case Studies

Case 1: PharmaHealth Solutions

Developed novel JAK2 inhibitor using our compound as key intermediate:
– Reduced synthesis steps from 12 to 8
– Improved final API purity to 99.7%
– Accelerated preclinical timeline by 5 months

Case 2: AgroShield Ltd

Created systemic fungicide formulation:
– 92% disease suppression in wheat trials
– 30-day residual activity vs 21-day industry standard
– Passed OECD 201/202 ecotoxicity tests

5. Inquiry and Customization Support

Our technical team provides:
– Custom bromination services
– Batch-specific analytical reports (HPLC, GC-MS, NMR)
– Regulatory documentation support (REACH, TSCA)

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826

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