Comprehensive Guide to METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL
Table of Contents
- Product Overview & Specifications
- Key Applications & Industrial Uses
- Operational Guidelines
- Comparative Analysis with Analogues
- Client Implementation Case Studies
- Procurement & Technical Support
1. Product Overview & Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 220641-87-2 |
| Chemical Formula | C6H13NO·HCl |
| Molecular Weight | 151.64 g/mol |
| Synonyms | N-Methyl-tetrahydro-2H-pyran-4-amine hydrochloride 4-(Methylamino)tetrahydropyran HCl |
| Appearance | White crystalline powder |
| Purity | ≥96% (HPLC) |
| Packaging | 1kg foil bags, 25kg fiber drums |
| Storage | 2-8°C in dry environment |
2. Key Applications & Industrial Uses
This heterocyclic amine hydrochloride derivative serves critical functions in:
- Pharmaceutical intermediates for CNS drug development
- Ligand synthesis in asymmetric catalysis
- Building block for bioactive molecule construction
- Precursor in agrochemical formulations
- Chiral resolving agents in fine chemical production
3. Operational Guidelines
Handling Protocols:
Use NIOSH-approved respirators and neoprene gloves. Conduct operations under inert atmosphere (N2/Ar) when processing in solution phase.
Solubility Profile:
| Solvent | Solubility (mg/mL) |
|---|---|
| Water | 82.3 |
| Methanol | 145.6 |
| DCM | 89.4 |
4. Comparative Analysis
| Parameter | THP-4-Methylamine HCl | Piperidine Derivatives |
|---|---|---|
| Ring Strain | Low (Chair conformation) | Moderate |
| pKa | 9.2±0.3 | 10.1±0.4 |
| Thermal Stability | Stable to 180°C | Decomposes at 150°C |
5. Client Implementation Case Studies
Case 1: CNS Drug Development
A Shanghai-based pharma company utilized this compound as a key intermediate in developing novel dopamine D3 receptor antagonists, achieving 92% yield in Buchwald-Hartwig amination steps.
Case 2: Catalytic Ligand Synthesis
German chemical researchers created chiral phosphine ligands using THP-protected amine groups, demonstrating 98% ee in asymmetric hydrogenation trials.
6. Procurement & Technical Support
For pricing, COA documentation, and bulk orders:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Our technical team provides:
- Custom synthesis scale-up services
- Regulatory compliance documentation
- Application-specific formulation guidance


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