1-Acetylpiperazine (CAS 5925-76-0) is a nitrogen-containing heterocyclic compound with molecular formula C6H12N2O. It serves as a critical intermediate in pharmaceutical synthesis and specialty chemicals.
Parameter | Specification | Piperazine | 1-Methylpiperazine |
---|---|---|---|
Purity | ≥99.5% | 98.0% | 99.0% |
Melting Point | 34-36°C | 106°C | -60°C |
Solubility in Water | Miscible | Highly soluble | Limited |
Used in synthesis of antipsychotics (e.g., Aripiprazole) and antidepressants through nucleophilic substitution reactions.
Acts as catalyst in Buchwald-Hartwig aminations and ligand in transition metal catalysis for C-N bond formation.
Client: Jiangsu Hengrui Pharmaceuticals
Application: Aprepitant antiemetic production scale-up
Result: Reduced reaction steps from 5 to 3, 18% cost savings
Client: Syngenta AG
Application: Fungicide molecular stabilization
Result: Increased field efficacy duration by 40%
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