Comprehensive Guide to 2-Chloro-3-methylpyridine: Properties, Applications, and Case Studies

1. Product Overview & Specifications

2-Chloro-3-methylpyridine (CAS 18368-63-5) is a halogenated pyridine derivative widely used in pharmaceuticals, agrochemicals, and organic synthesis. Below are its key specifications:

Parameter Value
CAS Number 18368-63-5
Molecular Formula C6H6ClN
Molecular Weight 127.57 g/mol
Appearance Colorless to pale yellow liquid
Purity ≥98% (GC)
Storage 2-8°C in airtight containers

Comparative Advantages

Feature 2-Chloro-3-methylpyridine Similar Compounds
Reactivity High selectivity in nucleophilic substitutions Lower reactivity in 2-chloro-4-methylpyridine
Stability Stable under inert atmospheres Prone to decomposition in 3-chloro-2-methylpyridine

2. Key Applications of 2-Chloro-3-methylpyridine

Pharmaceutical Intermediates

Used in synthesizing antihistamines, antiviral agents, and kinase inhibitors due to its electron-deficient aromatic ring.

Agrochemical Synthesis

Critical for producing herbicides and insecticides, leveraging its chlorine substituent for bioactivity.

Organic Synthesis

Serves as a building block for ligands, catalysts, and functionalized polymers.

3. Practical Use Cases

Case 1: Antiviral Drug Intermediate

In the synthesis of Remdesivir analogs, 2-Chloro-3-methylpyridine enabled a 20% yield improvement via optimized coupling reactions.

Case 2: Herbicide Production

A major agrochemical company reduced synthesis steps from 5 to 3 by using this compound as a key intermediate.

4. Client Success Stories

Client A: Top-10 Pharma Company

Challenge: Low yield in kinase inhibitor synthesis.
Solution: Optimized reaction with 2-Chloro-3-methylpyridine.
Result: 35% cost reduction and accelerated FDA approval.

Client B: Agrochemical Innovator

Challenge: Unstable intermediates in herbicide production.
Solution: Switched to 2-Chloro-3-methylpyridine-based synthesis.
Result: 50% fewer side reactions and 99% final product purity.

5. Request a Quote or Technical Support

Contact us for premium 2-Chloro-3-methylpyridine tailored to your needs:

Our experts provide:

  • Custom synthesis (purity 98-99.9%)
  • Bulk pricing (1kg to ton-scale)
  • Regulatory documentation support

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