2-Chloro-3-methylpyridine (CAS 18368-63-5) is a halogenated pyridine derivative widely used in pharmaceuticals, agrochemicals, and organic synthesis. Below are its key specifications:
| Parameter | Value |
|---|---|
| CAS Number | 18368-63-5 |
| Molecular Formula | C6H6ClN |
| Molecular Weight | 127.57 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | ≥98% (GC) |
| Storage | 2-8°C in airtight containers |
| Feature | 2-Chloro-3-methylpyridine | Similar Compounds |
|---|---|---|
| Reactivity | High selectivity in nucleophilic substitutions | Lower reactivity in 2-chloro-4-methylpyridine |
| Stability | Stable under inert atmospheres | Prone to decomposition in 3-chloro-2-methylpyridine |
Used in synthesizing antihistamines, antiviral agents, and kinase inhibitors due to its electron-deficient aromatic ring.
Critical for producing herbicides and insecticides, leveraging its chlorine substituent for bioactivity.
Serves as a building block for ligands, catalysts, and functionalized polymers.
In the synthesis of Remdesivir analogs, 2-Chloro-3-methylpyridine enabled a 20% yield improvement via optimized coupling reactions.
A major agrochemical company reduced synthesis steps from 5 to 3 by using this compound as a key intermediate.
Challenge: Low yield in kinase inhibitor synthesis.
Solution: Optimized reaction with 2-Chloro-3-methylpyridine.
Result: 35% cost reduction and accelerated FDA approval.
Challenge: Unstable intermediates in herbicide production.
Solution: Switched to 2-Chloro-3-methylpyridine-based synthesis.
Result: 50% fewer side reactions and 99% final product purity.
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