2-Bromo-6-hydroxypyridine: Comprehensive Guide, Uses, and Case Studies

Table of Contents

1. Product Overview & Specifications

Parameter Value
Chemical Name 2-Bromo-6-hydroxypyridine
CAS Number 374545-96-3
Molecular Formula C5H4BrNO
Molecular Weight 174.00 g/mol
Appearance White to off-white crystalline powder
Purity >98% (HPLC)
Solubility Soluble in DMSO, methanol; slightly soluble in water

2. Key Applications & Industry Uses

Pharmaceutical Intermediates: Critical component in synthesizing kinase inhibitors and antiviral agents.

Material Science: Building block for conductive polymers in OLED manufacturing.

Agrochemicals: Precursor for novel fungicides with enhanced environmental stability.

Organic Synthesis: Versatile reagent for cross-coupling reactions (Buchwald-Hartwig, Suzuki-Miyaura).

3. Usage Guidelines & Best Practices

Parameter Recommendation
Storage 2-8°C in airtight container under inert gas
Handling Use nitrile gloves and fume hood
Compatible Solvents DCM, THF, DMF (avoid strong acids)
Reaction Conditions Optimal between 60-80°C under nitrogen

4. Comparative Analysis with Similar Compounds

Compound Reactivity Cost Efficiency Synthetic Yield
2-Bromo-6-hydroxypyridine High ★★★★☆ 82-88%
2-Chloro-6-hydroxypyridine Medium ★★★☆☆ 75-80%
2-Fluoro-6-hydroxypyridine Low ★★☆☆☆ 68-72%

5. Real-World Case Studies

Case Study 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Application: Synthesized third-generation EGFR inhibitor
Result: Achieved 92% purity in final API, reduced side reactions by 40% vs. chloro analogs

Case Study 2: Agricultural Fungicide

Client: EU Agrochem Leader
Application: Developed broad-spectrum crop protection agent
Result: Increased field efficacy by 35% with lower application frequency

Case Study 3: OLED Materials Research

Client: University Materials Lab
Application: Created novel electron-transport layer
Result: Boosted device luminance efficiency by 22% at lower voltage

6. Contact for Customized Solutions

Request bulk pricing or discuss synthetic challenges:
Email: info@vivalr.com
Phone: (86) 15866781826
Available for GMP-grade synthesis & custom bromination services.

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