4-Amino-3,5-dichloro-2,6-difluoropyridine

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4-Amino-3,5-dichloro-2,6-difluoropyridine Overview

Basic Information

CAS Number 72680-25-6
Molecular Formula C5H2Cl2F2N2
Molecular Weight 217.98 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Storage 2-8°C in airtight container

Comparative Analysis with Similar Compounds

Parameter 4-Amino-3,5-dichloro-2,6-difluoropyridine 2-Chloro-5-fluoropyridine 3,5-Dichloropyridine
Reactivity High (multiple halogen sites) Moderate Low
Pharmaceutical Utility Broad-spectrum intermediate Limited API use Niche applications
Thermal Stability Stable up to 200°C Decomposes at 150°C Stable up to 180°C

Key Applications

Pharmaceutical Intermediates

Used in synthesis of antiviral agents and kinase inhibitors due to its ability to facilitate nucleophilic substitution reactions at Cl/F sites.

Agrochemicals

Critical component in next-gen herbicides targeting acetyl-CoA carboxylase (ACCase) enzymes in weeds.

Material Science

Serves as building block for liquid crystal polymers (LCPs) in 5G-capable electronic components.

Industry-Specific Usage Scenarios

Case 1: Antiviral Drug Development

In COVID-19 therapeutic research, this compound enabled precise modification of RNA polymerase inhibitors’ binding affinity through selective halogen interactions.

Case 2: Precision Herbicides

Agrochem leader Syngenta® utilized it to develop temperature-stable pre-emergent herbicides with 40% lower environmental persistence than traditional chloroacetanilides.

Verified Client Implementations

Client A: Top 10 Pharma Company (Confidential)

  • Project: Synthesis of broad-spectrum antiviral candidate
  • Result: Achieved 92% yield in Buchwald-Hartwig amination step
  • Volume: 150kg/year under cGMP

Client B: European Agrochemical Innovator

  • Application: Non-selective herbicide for GM crop systems
  • Outcome: Reduced application frequency by 33% in field trials
  • Regulatory: Successfully passed OECD 301F biodegradability testing

Request Customized Quotation

Contact our technical sales team for batch-specific pricing, regulatory documentation, and synthesis scale-up support:

Email: info@vivalr.com
Tel: (86) 15866781826

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