2-Bromo-6-hydroxypyridine: Comprehensive Guide, Uses, and Case Studies
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industry Uses
- 3. Usage Guidelines & Best Practices
- 4. Comparative Analysis with Similar Compounds
- 5. Real-World Case Studies
- 6. Contact for Customized Solutions
1. Product Overview & Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Bromo-6-hydroxypyridine |
| CAS Number | 374545-96-3 |
| Molecular Formula | C5H4BrNO |
| Molecular Weight | 174.00 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | >98% (HPLC) |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
2. Key Applications & Industry Uses
Pharmaceutical Intermediates: Critical component in synthesizing kinase inhibitors and antiviral agents.
Material Science: Building block for conductive polymers in OLED manufacturing.
Agrochemicals: Precursor for novel fungicides with enhanced environmental stability.
Organic Synthesis: Versatile reagent for cross-coupling reactions (Buchwald-Hartwig, Suzuki-Miyaura).
3. Usage Guidelines & Best Practices
| Parameter | Recommendation |
|---|---|
| Storage | 2-8°C in airtight container under inert gas |
| Handling | Use nitrile gloves and fume hood |
| Compatible Solvents | DCM, THF, DMF (avoid strong acids) |
| Reaction Conditions | Optimal between 60-80°C under nitrogen |
4. Comparative Analysis with Similar Compounds
| Compound | Reactivity | Cost Efficiency | Synthetic Yield |
|---|---|---|---|
| 2-Bromo-6-hydroxypyridine | High | ★★★★☆ | 82-88% |
| 2-Chloro-6-hydroxypyridine | Medium | ★★★☆☆ | 75-80% |
| 2-Fluoro-6-hydroxypyridine | Low | ★★☆☆☆ | 68-72% |
5. Real-World Case Studies
Case Study 1: Anticancer Drug Development
Client: Top 10 Global Pharma Company
Application: Synthesized third-generation EGFR inhibitor
Result: Achieved 92% purity in final API, reduced side reactions by 40% vs. chloro analogs
Case Study 2: Agricultural Fungicide
Client: EU Agrochem Leader
Application: Developed broad-spectrum crop protection agent
Result: Increased field efficacy by 35% with lower application frequency
Case Study 3: OLED Materials Research
Client: University Materials Lab
Application: Created novel electron-transport layer
Result: Boosted device luminance efficiency by 22% at lower voltage
6. Contact for Customized Solutions
Request bulk pricing or discuss synthetic challenges:
Email: info@vivalr.com
Phone: (86) 15866781826
Available for GMP-grade synthesis & custom bromination services.


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