Comprehensive Guide to 2-Chloro-3-Fluoropyridine-4-Boronic Acid
Table of Contents
- Product Overview & Specifications
- Applications in Pharmaceutical & Chemical Industries
- Usage Guidelines & Best Practices
- Case Studies
- Procurement Guide
- Contact for Quotation
1. Product Overview & Specifications
CAS No.: 1072941-46-1
Molecular Formula: C5H3BClFNO2
Molecular Weight: 189.34 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥97% (HPLC)
Storage: -20°C, under inert atmosphere
Comparative Analysis with Similar Boronic Acids
| Parameter | 2-Chloro-3-Fluoropyridine-4-Boronic Acid | 4-Fluorophenylboronic Acid | 5-Chloropyridine-3-boronic Acid |
|---|---|---|---|
| Reactivity in Suzuki Coupling | High (due to Cl/F substituents) | Moderate | High |
| Pharmaceutical Applications | Kinase inhibitor intermediates | Antibiotic synthesis | Antiviral agents |
2. Key Applications
Pharmaceutical Synthesis
- Intermediate for tyrosine kinase inhibitors (e.g., EGFR inhibitors)
- Building block for fluorinated API candidates
Agrochemical Development
- Synthesis of novel pesticides with improved environmental stability
3. Usage Guidelines
Handling Precautions
- Use dry, oxygen-free solvents for reactions
- Recommended catalyst: Pd(PPh3)4
4. Case Studies
Case 1: PharmaCorp’s Oncology Drug Development
Application: Synthesis of third-generation EGFR inhibitor
Result: Achieved 92% yield in Suzuki-Miyaura coupling
Case 2: AgroChem Ltd’s Herbicide Formulation
Application: Creation of moisture-resistant fungicide
5. Procurement Guide
| Supplier | Minimum Order | Lead Time |
|---|---|---|
| Vivalr Chemicals | 100g | 2-3 weeks |
6. Request Customized Solution
Email: info@vivalr.com
Tel: (86) 15866781826
Request SDS, COA, or bulk pricing.
相关产品
Chemical Name: Tribehenin
Cas No.: 18641-57-1
Molecular Fomula: C69H134O6
Molecular Weight: 1059.8
Appearance: White waxy powder or solid
Chemical Name: Oxirane, methyl-, polymer with oxirane, dodecyl ether
Cas No.: 68238-81-3
Molecular Fomula: C17H36O3
Molecular Weight: 288.46594
Chemical Name: 1-[9-ethyl-6-(4-fluoro-benzoyl)-9H-carbazol-3-yl]-ethanone
Cas No.: 876907-97-0
Molecular Fomula: C23H18FNO2
Molecular Weight: 359.39
Chemical Name: STODDARD SOLVENT
CAS No.: 64742-88-7
Appearance: Colorless or Light Yellow Liquid
Chemical Name: 1,5-Diphenylcarbazide
Synonyms: 1,5-Diphenylcarbohydrazide; 2,2’-diphenylcarbazide; Diphenylcartazide; sym-diphenylcarbazide
CAS No.: 140-22-7
Molecular Formula: C13H14N4O
Molecular Weight: 242.28
Chemical Name: Potassium Castorate
CAS No.: 8013-05-6
Molecular Formula: C57H107K3O12
Molecular Weight: 1101.74718
Appearance: Yellow Liquid
Common English name: 5-iodo-2,3-dihydropyridazin-3-one
CAS No.: 825633-94-1
Molecular formula: C4H3IN2O
Molecular weight: 221.98
Sample: Available
Chemical Name: Dehydrocholic acid
Synonyms: Acide dehydrocholique; Triketocholanic acid
CAS No.: 81-23-2
Molecular Formula: C24H34O5
Molecular Weight: 402.53
Appearance: Powder
Chemical Name: 1,1,2,2-Tetrachloroethane
Other Name: Tetrachlorethane
CAS No.: 79-34-5
Molecular Formula: C2H2Cl4
Molecular Weight: 167.85
Appearance: Liquid
Chemical Name: Eicosatetraynoic acid(ETYA)
Cas No.: 1191-85-1
Molecular Fomula: C20H24O2
Molecular Weight: 296.4
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: o-Xylene
Synonyms: 1,2-Dimethylbenzene; ortho-xylene
CAS No.: 95-47-6
Molecular Formula: C8H10
Molecular Weight: 106.17
评论
目前还没有评论。