2-FLUORO-1-METHYLPYRIDINIUM P-TOLUENESULFONATE

1. Product Overview & Specifications

2-Fluoro-1-methylpyridinium p-Toluenesulfonate (CAS No. 58086-67-2) is a fluorinating reagent widely used in organic synthesis. Its molecular formula is C₁₃H₁₄FNO₃S, with a molecular weight of 295.32 g/mol.

2. Key Applications

• Fluorination Reactions: Efficiently introduces fluorine atoms into aromatic and heteroaromatic compounds.
• Pharmaceutical Intermediates: Critical in synthesizing fluorinated APIs (Active Pharmaceutical Ingredients).
• Material Science: Used to modify polymer properties via fluorination.
• Agrochemicals: Enhances bioactivity and stability of pesticides.

3. Usage Guidelines

1. Handling: Use under inert atmosphere (N₂ or Ar) due to moisture sensitivity.
2. Solubility: Soluble in polar aprotic solvents (e.g., DMF, DMSO, acetonitrile).
3. Reaction Conditions: Typical reactions occur at 60–100°C for 4–12 hours.
4. Safety: Wear PPE (gloves, goggles) and avoid inhalation.

4. Case Studies

Case 1: Fluorinated Anticancer Drug Intermediate

A leading pharmaceutical company utilized this reagent to synthesize a fluorinated analog of a tyrosine kinase inhibitor, achieving 85% yield and >99% selectivity.

Case 2: High-Performance Polymer Modification

A materials science lab enhanced the thermal stability of polyimide films by incorporating fluorine groups, improving decomposition temperature by 40°C.

5. Client Testimonials

Shanghai Advanced PharmaTech

“Consistent quality and reliable reactivity reduced our API development cycle by 30%.”

Guangzhou AgroChem Solutions

“The reagent’s selectivity allowed us to optimize a next-generation herbicide with minimal byproducts.”

6. Contact for Quotation

For pricing, bulk orders, or technical inquiries:

Email: info@vivalr.com
Phone: (86) 15866781826