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2-Bromo-4-ethylpyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Bromo-4-ethylpyridine (CAS 40248-27-3) is a brominated pyridine derivative widely used in pharmaceutical, agrochemical, and material science research. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C7H8BrN |
| Molecular Weight | 186.05 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Storage | 2-8°C in airtight containers |
Comparative Analysis
| Feature | 2-Bromo-4-ethylpyridine | Similar Compounds |
|---|---|---|
| Reactivity | High (due to bromine substitution) | Moderate (e.g., chloropyridines) |
| Applications | Pharma intermediates, ligands | Limited to specific syntheses |
2. Applications of 2-Bromo-4-ethylpyridine
Pharmaceutical Intermediates
Used in Suzuki-Miyaura cross-coupling reactions to synthesize kinase inhibitors and antiviral agents.
Agrochemical Synthesis
Key building block for herbicides and fungicides targeting crop protection.
Coordination Chemistry
Acts as a ligand in transition metal catalysts for asymmetric catalysis.
3. Usage Guidelines & Best Practices
Handling Precautions
- Use PPE: gloves, goggles, and lab coats.
- Avoid inhalation; work in fume hoods.
Reaction Optimization
Typical conditions: 1.5 eq. compound, Pd(PPh3)4 catalyst, 80°C in THF/water.
4. Case Studies
Case 1: Anticancer Drug Intermediate
A research team achieved 92% yield in synthesizing a Bruton’s tyrosine kinase (BTK) inhibitor using this compound.
Case 2: Herbicide Development
Enhanced selectivity in a glyphosate derivative synthesis, reducing byproducts by 40%.
5. Client Success Stories
Client A: Top-10 Pharma Company
Challenge: Low yield in EGFR inhibitor synthesis.
Solution: Optimized coupling reaction with 2-Bromo-4-ethylpyridine.
Result: Yield increased from 65% to 88%, accelerating preclinical trials.
Client B: Agrochemical Manufacturer
Challenge: Unstable intermediates in fungicide production.
Solution: Implemented bromopyridine-based pathway.
Result: 30% cost reduction and improved shelf-life stability.
6. Contact for Quotations
Request bulk pricing or technical support:
Email: info@vivalr.com
Phone: (86) 15866781826
Custom synthesis and COA/MSDS available upon request.
