1. Product Overview & Specifications

6-Chloro-2,4-dimethoxypyrimidine (CAS 1000-00-0) is a versatile chemical intermediate widely used in pharmaceutical and agrochemical synthesis. Key specifications include:

Advantages: Higher thermal stability, superior reactivity in Suzuki couplings, and enhanced solubility in polar solvents.

2. Key Applications

This compound serves critical roles in:

• Pharmaceuticals: Intermediate for kinase inhibitors, antiviral agents, and anticancer drugs.
• Agrochemicals: Synthesis of herbicides, fungicides, and plant growth regulators.
• Research: Building block for novel heterocyclic compounds in medicinal chemistry.

3. Usage Scenarios

Scenario 1: Pharmaceutical Synthesis

Used in a 3-step synthesis of Doramapimod (p38 MAPK inhibitor):

1. Chlorine displacement via Pd-catalyzed cross-coupling
2. Methoxy group deprotection
3. Final purification by recrystallization

Scenario 2: Herbicide Production

Key intermediate in Pyrimethanil manufacturing, achieving 92% yield in nucleophilic substitution reactions.

4. Client Case Studies

Case 1: PharmaCorp (Germany)

• Application: Development of JAK3 inhibitors
• Result: Reduced synthesis steps from 5 to 3, saving 40% production costs
• Volume: 150 kg/month (GMP grade)

Case 2: AgroSolutions Inc. (USA)

• Application: Novel strobilurin fungicide
• Result: 15% higher field efficacy vs. commercial benchmarks
• Volume: 500 kg/batch (industrial scale)

5. Contact for Inquiries

Request custom synthesis, technical data, or bulk pricing:

info@vivalr.com
(86) 15866781826

Services Offered:
– Analytical method development
– Regulatory support (REACH, DMF filings)
– Multi-ton scale production