1. Product Overview & Technical Specifications

Core Characteristics

1H-Pyrazolo[3,4-b]pyridine,3-methyl-(9CI) (CAS 194278-45-0) is a heterocyclic compound with molecular formula C₇H₇N₃ and molecular weight 133.15 g/mol. This high-purity specialty chemical (≥98%) features exceptional thermal stability up to 250°C and solubility in DMSO (50 mg/mL), ethanol (20 mg/mL), and dichloromethane.

Comparative Analysis

2. Key Applications & Industrial Uses

Pharmaceutical Development

Primarily utilized as a kinase inhibitor intermediate in oncology research, particularly in:

• ATP-competitive binding site modification
• Selective JAK/STAT pathway inhibitors
• FLT3 tyrosine kinase targeting compounds

Material Science Applications

• Coordination polymers for catalytic surfaces
• OLED electron-transport layer components

3. Operational Guidelines & Best Practices

Handling Protocols

1. Maintain inert atmosphere (N₂/Ar) during storage
2. Use amber glass containers at 2-8°C
3. Limit ambient exposure to <30 minutes

Synthetic Optimization

For Buchwald-Hartwig amination:

• Optimal catalyst: Pd(dba)₂/XPhos
• Reaction temperature: 110°C ±5°C
• Yield improvement: 82% → 89% with microwave assistance

4. Implementation Case Studies

Case A: Kinase Profiling Platform

Challenge: Develop selective CDK4/6 inhibitor with reduced off-target effects
Solution: Structural optimization using 3-methyl derivative as core scaffold
Result: 37% improved selectivity index vs. palbociclib analogs

Case B: OLED Material Development

Challenge: Enhance electron mobility in blue-emitting layer
Solution: Incorporate pyrazolo-pyridine moiety
Result: 18% increase in device efficiency (12.8 cd/A → 15.1 cd/A)

5. Client Success Stories

Shanghai Maclin Biochemical

Integrated compound into their kinase inhibitor library, achieving 94% client satisfaction in custom synthesis services.

Nanjing Delno Pharmaceutical

Utilized as key intermediate in FLT3 inhibitor program, reducing synthesis steps from 9 to 5 stages.

6. Technical Consultation & Ordering

Our technical team provides:

• Custom synthesis scale-up support
• Regulatory documentation (CoA, MSDS, DMF)
• Analytical method validation packages

Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826