2-Fluoro-6-formylpyridine: Comprehensive User Guide for Researchers and Industry Professionals
Table of Contents
1. Product Overview and Specifications
Chemical Profile
| Parameter | 2-Fluoro-6-formylpyridine | Similar Compounds |
|---|---|---|
| CAS Number | 374593-49-4 | N/A |
| Molecular Formula | C6H4FNO | C6H5NO (Pyridine-2-carboxaldehyde) |
| Molecular Weight | 125.10 g/mol | 107.11 g/mol |
| Purity | >98% (HPLC) | 90-95% |
| Storage | 2-8°C in dark | Room temperature |
Differentiation Factors: Enhanced electrophilicity from fluorine substitution enables superior reactivity in nucleophilic aromatic substitution compared to non-fluorinated analogs.
2. Key Applications and Use Cases
Pharmaceutical Intermediates
Widely utilized in synthesizing kinase inhibitors and antiviral agents through:
- Schiff base formation via aldehyde group
- Fluorine-directed C-H activation
Agrochemical Development
Critical component in novel pesticide synthesis:
- Herbicide lead optimization
- Fungicide metabolite production
3. Operational Guidelines and Best Practices
Reaction Optimization
| Reaction Type | Recommended Conditions | Yield Range |
|---|---|---|
| Amine Condensation | EtOH, 60°C, 12h | 75-85% |
| Cross Coupling | Pd(OAc)₂, K₂CO₃, DMF | 60-70% |
Safety Protocols
- Use nitrile gloves and chemical goggles
- Maintain pH-neutral environment
4. Industry Case Studies
Case 1: Top-tier Pharma Company
Application: JAK3 inhibitor development
Result: 40% improvement in binding affinity vs non-fluorinated analogs
Case 2: Agrochemical Leader
Application: Next-gen herbicide formulation
Result: 3x faster degradation profile meeting EPA guidelines
5. Technical Support and Inquiry
Contact our chemistry experts for:
- Custom synthesis options
- Bulk order pricing (100g+ quantities)
- MSDS documentation
Email: info@vivalr.com
Tel: (86) 15866781826
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