Parameter | 2,6-Dichloropyridine N-Oxide | Standard Pyridine Derivatives |
---|---|---|
CAS Number | 2587-00-0 | Varies by compound |
Molecular Formula | C5H3Cl2NO | Typically C5H5N variants |
Purity | ≥98% (HPLC) | 90-95% (average) |
Thermal Stability | Stable up to 200°C | 150-180°C (typical) |
HS Code | 29333990.90 | 29333990.xx |
Process Stage | Recommended Conditions |
---|---|
Storage | -20°C in inert atmosphere |
Reaction Solvent | Dry DCM or THF |
Catalytic Use | 0.5-2 mol% with Pd complexes |
Safety Protocols | Class II ventilated hood required |
Challenge: Achieve >99% regioselectivity in nucleophilic substitution
Solution: 1.2 eq. 2,6-Dichloropyridine N-Oxide in DMF at 80°C
Outcome: 92% yield with 99.3% purity
Application: High-throughput synthesis of kinase inhibitors
Annual Usage: 15kg (GMP-grade)
Performance: Reduced reaction steps from 7 to 4 in API synthesis
Contact our technical team for batch optimization or custom synthesis:
Email: info@vivalr.com
Tel: (86) 15866781826
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