3-Fluoro-2-Iodopyridine: Technical Guide & Procurement Insights
Table of Contents
- Product Overview & Key Specifications
- Comparative Analysis with Related Compounds
- Applications in Pharmaceutical & Industrial Chemistry
- Operational Case Studies
- Client Success Stories
- Request Customized Quotation
Product Overview & Key Specifications
CAS Number: 374624-24-3
Molecular Formula: C5H3FIN
Appearance: White to pale yellow crystalline powder
Purity: ≥98% (HPLC)
Storage: 2-8°C in inert atmosphere
Comparative Analysis with Related Compounds
| Parameter | 3-Fluoro-2-Iodopyridine | 2-Fluoro-3-Iodopyridine | 3-Chloro-2-Iodopyridine |
|---|---|---|---|
| Electrophilic Reactivity | High (Iodine-directed) | Moderate | Low |
| Cross-Coupling Efficiency | 92-95% | 85-88% | 78-82% |
| Pharma Intermediate Usage | Level 1 Priority | Level 2 | Level 3 |
Applications in Pharmaceutical & Industrial Chemistry
A. Kinase Inhibitor Synthesis: Key building block for Bruton’s tyrosine kinase (BTK) inhibitors
B. Radiopharmaceuticals: 123I-labeled derivatives for diagnostic imaging
C. Agrochemicals: Precursor for novel neonicotinoid alternatives
D. Material Science: Ligand in OLED electron-transport layers
Operational Case Studies
Case 1: Suzuki-Miyaura Coupling Optimization
– Substrate: 3-Fluoro-2-Iodopyridine + Phenylboronic acid
– Conditions: Pd(OAc)2/SPhos, K3PO4, 80°C
– Yield: 94% (vs. 82% with chloro analog)
Client Success Stories
Client 1: Top-10 Pharma Company (Basel)
– Application: EGFR T790M inhibitor intermediate
– Batch Size: 150kg
– Purity Requirement: 99.5%
– Outcome: 18-month stable supply contract
Client 2: Japanese Agrochemical Innovator
– Usage: Systemic insecticide R&D
– Technical Support: Custom fluorination protocol
– Result: Patent filed (JP2024-045678)
Request Customized Quotation
Contact our technical team for:
– Batch-specific COA
– Regulatory support (REACH, TSCA)
– Custom synthesis options
Email: info@vivalr.com
Tel: (86) 15866781826
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