Ethyl 2-Bromopropionate (CAS 535-11-5): Comprehensive Product Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Ethyl 2-Bromopropionate | Ethyl 3-Bromopropionate | Ethyl 2-Chloropropionate |
|---|---|---|---|
| CAS Number | 535-11-5 | 41145-84-0 | 535-13-7 |
| Molecular Formula | C5H9BrO2 | C7H13BrO2 | C5H9ClO2 |
| Molecular Weight | 181.03 g/mol | 217.08 g/mol | 136.58 g/mol |
| Boiling Point | 156-160°C | 162-165°C | 145-148°C |
| Density (20°C) | 1.394 g/mL | 1.24 g/mL | 1.112 g/mL |
| Flash Point | 51°C | 62°C | 42°C |
Key Differentiator: Superior reactivity in nucleophilic substitution reactions compared to chloro derivatives, with 99% purity for precision synthesis.
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Facilitates synthesis of chiral molecules in antihypertensive APIs through stereoselective alkylation.
Agrochemical Production
Critical precursor for pyrethroid insecticide side chains, enabling 18% yield improvement over traditional methods.
Advanced Material Synthesis
Enables creation of UV-resistant polymer additives with 92% thermal stability at 200°C.
3. Operational Guidelines & Best Practices
Storage Protocol
- Maintain under inert gas (N2) at 4-8°C
- Amber glass containers with PTFE-lined caps
- Shelf life: 24 months unopened
Reaction Optimization
- Use 1.2:1 molar ratio in SN2 reactions
- Optimal temperature range: 40-60°C
- Recommended solvents: Anhydrous THF or DMF
4. Industry-Specific Use Cases
Case A: Anticancer Drug Intermediate
Used in 5-step synthesis of tyrosine kinase inhibitors, achieving 78% overall yield with 99.5% chiral purity.
Case B: Liquid Crystal Precursor
Key component in fluorinated mesogen production for 4K OLED displays, reducing response time by 22ms.
5. Client Success Stories
Client 1: Leading Pharma Innovator
- Application: Hepatitis C protease inhibitors
- Result: Accelerated scale-up from 10g to 200kg batches
- Purity: Consistently >99.8% by HPLC
Client 2: Specialty Chemical Manufacturer
- Application: Flame retardant additives
- Result: Achieved UL94 V-0 rating with 15% load
- Throughput: 8MT/month continuous production
6. Request Customized Solutions
Optimize your synthesis workflow with technical support from our chemists:
- Email: info@vivalr.com
- Phone: (86) 15866781826
Request batch-specific COA and regulatory documentation.



评论
目前还没有评论。