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Specialized inHexanoyl chloride CAS 142-61-0and related product development and production

Chemical Name: Hexanoyl chloride
CAS No.: 142-61-0
Appearance: Clear colorless to pale yellow liquid
Assay：99%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Hexanoyl Chloride (CAS 142-61-0): Technical Guide

Table of Contents

1. Product Overview & Specifications

Chemical Identity

  • IUPAC Name: Hexanoyl chloride
  • CAS No.: 142-61-0
  • Molecular Formula: C6H11ClO
  • Molecular Weight: 134.60 g/mol
  • EINECS: 205-549-1

Physical Properties

Parameter Value
Appearance Colorless to pale yellow liquid
Melting Point -87°C
Boiling Point 150–153°C (lit.)
Density 0.963 g/mL at 25°C
Refractive Index n20/D: 1.426
Flash Point 50°C (closed cup)
Solubility Miscible with ether, chloroform; decomposes in water/ethanol

2. Applications & Industrial Uses

Key Applications

  • Organic Synthesis: Primary reagent for introducing hexanoyl groups in pharmaceuticals, agrochemicals, and polymers.
  • Pharmaceutical Intermediates: Used in synthesizing active pharmaceutical ingredients (APIs) such as anticonvulsants and lipid regulators.
  • Agrochemicals: Precursor for herbicides and fungicides.
  • Polymer Chemistry: Modifies surface properties of polymers for enhanced stability.

Functional Advantages

  • High reactivity in acylation reactions under mild conditions.
  • Compatible with Grignard reagents and Friedel-Crafts alkylation.

3. Operational Guidelines

Handling & Storage

  • Storage: Keep in sealed containers under inert gas (N2 or Ar) at 2–8°C.
  • Moisture Control: Use molecular sieves or calcium chloride to prevent hydrolysis.
  • Ventilation: Operate in fume hoods with ≤50% relative humidity.

Reaction Optimization

  • Use anhydrous solvents (e.g., THF, dichloromethane).
  • Maintain stoichiometric excess (1.2–1.5 eq) for complete conversion.

4. Safety Protocols

Hazard Classification (GHS)

  • Flammability: Category 3 (Flash point 50°C)
  • Corrosivity: Skin Corrosion/Irritation (Category 1A)
  • Acute Toxicity: Oral (Category 4), Inhalation (Category 3)

Emergency Response

Exposure Route Action
Skin Contact Flush with water ≥15 min; remove contaminated clothing
Eye Contact Irrigate with saline ≥10 min; seek ophthalmological evaluation
Inhalation Move to fresh air; administer oxygen if dyspnea occurs
Fire Use CO2, dry chemical, or sand; avoid water

5. Client Case Studies

Case 1: Pharmaceutical Intermediate Production

  • Client: European CRO
  • Application: Synthesis of antiepileptic drug intermediate
  • Outcome: 92% yield improvement vs. alternative acylating agents

Case 2: Specialty Polymer Development

  • Client: US Materials Innovator
  • Application: Hydrophobic coating for medical devices
  • Outcome：Achieved 40% reduction in surface energy

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

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Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
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More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
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About the company

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FAQ

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Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

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Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

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5000+

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150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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