3-Guanidinopropionic acid CAS 353-09-3

3-Guanidinopropionic Acid (CAS 353-09-3) Comprehensive Product Guide

1. Product Specifications & Comparative Analysis

2. Key Applications & Industrial Uses

2.1 Biomedical Research

• Competitive inhibitor of creatine kinase in mitochondrial energy metabolism studies
• Induction of type 2 diabetes symptoms in animal models
• Muscle fatigue mechanism analysis

2.2 Pharmaceutical Development

• Lead compound for metabolic disorder therapeutics
• Molecular template for AMPK activators
• Chelating agent in drug formulation

3. Operational Guidelines & Best Practices

3.1 Handling Protocols

• Storage: Maintain at 2-8°C in inert atmosphere
• Solubility: 50 mg/mL in PBS buffer (pH 7.4)
• Stability: 24 months when protected from moisture

3.2 Experimental Design

• Recommended dosage: 1-3% in rodent feed for metabolic studies
• Cell culture applications: 0.5-2 mM concentration range
• Synergistic use with 31P-NMR for real-time energy monitoring

4. Verified Client Case Studies

4.1 University of Metabolic Research (2024)

• Application: Induced muscle insulin resistance in murine models
• Results: 68% phosphocreatine reduction observed via MRI
• Protocol: 8-week dietary administration at 2.5% concentration

4.2 Biotech Solutions Inc. (2023)

• Application: High-throughput screening of antidiabetic compounds
• Outcome: Identified 3 lead molecules with AMPK activation >200%
• Throughput: 15,000 compounds screened weekly

4.3 Sports Science Institute (2025)

• Application: Ergogenic aid comparison study
• Findings: 12% performance variance vs. conventional creatine
• Trial Scale: 120 athlete participants over 6 months

5. Technical Consultation & Ordering

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