Chemical Name: 3-Guanidinopropionic acid
CAS No.: 353-09-3
Appearance: Solid
Assay: 98%
Parameter | 3-Guanidinopropionic Acid | β-Guanidinopropionic Acid | Creatine Analogues |
---|---|---|---|
CAS Number | 353-09-3 | 1704-67-4 | Varies |
Molecular Formula | C4H9N3O2 | C4H9N3O2 | Dependent on type |
Bioactivity | Competitive creatine kinase inhibitor | Non-competitive inhibitor | Variable mechanisms |
Research Applications | Muscle metabolism studies, Diabetes research | Neurological studies | Sports nutrition |
• Competitive inhibitor of creatine kinase in mitochondrial energy metabolism studies
• Induction of type 2 diabetes symptoms in animal models
• Muscle fatigue mechanism analysis
• Lead compound for metabolic disorder therapeutics
• Molecular template for AMPK activators
• Chelating agent in drug formulation
• Storage: Maintain at 2-8°C in inert atmosphere
• Solubility: 50 mg/mL in PBS buffer (pH 7.4)
• Stability: 24 months when protected from moisture
• Recommended dosage: 1-3% in rodent feed for metabolic studies
• Cell culture applications: 0.5-2 mM concentration range
• Synergistic use with 31P-NMR for real-time energy monitoring
• Application: Induced muscle insulin resistance in murine models
• Results: 68% phosphocreatine reduction observed via MRI
• Protocol: 8-week dietary administration at 2.5% concentration
• Application: High-throughput screening of antidiabetic compounds
• Outcome: Identified 3 lead molecules with AMPK activation >200%
• Throughput: 15,000 compounds screened weekly
• Application: Ergogenic aid comparison study
• Findings: 12% performance variance vs. conventional creatine
• Trial Scale: 120 athlete participants over 6 months
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