Iodotrimethylsilane (CAS 16029-98-4): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Iodotrimethylsilane (CAS 16029-98-4) is a highly reactive organosilicon compound with the formula (CH3)3SiI. Key parameters:
| Parameter | Value |
|---|---|
| Molecular Weight | 200.11 g/mol |
| Purity | ≥98% |
| Boiling Point | 106-108°C |
Comparative Analysis with Similar Reagents
| Reagent | Reactivity | Stability |
|---|---|---|
| Iodotrimethylsilane | High (ideal for deprotection) | Moisture-sensitive |
| Chlorotrimethylsilane | Moderate | Air-stable |
2. Key Applications & Chemical Uses
- Hydroxyl Group Protection: Efficient silylating agent for alcohol protection in peptide synthesis.
- Deprotection Agent: Cleaves ethers and esters under mild conditions.
- Catalyst: Accelerates Friedel-Crafts alkylation reactions.
3. Usage Scenarios in Organic Synthesis
Case 1: Carbohydrate Derivatization
Used to protect hydroxyl groups in monosaccharide derivatives at 0°C with 90% yield.
Case 2: Drug Intermediate Synthesis
Critical in producing antiviral drug intermediates via selective deprotection.
4. Real-World Customer Case Studies
Client A: PharmaTech Solutions (USA)
Scaled up oseltamivir phosphate synthesis using iodotrimethylsilane for intermediate purification (Batch size: 500 kg).
Client B: EuroChem Research GmbH
Developed novel silicon-containing polymers with 15% improved thermal stability.
5. Request a Quote or Technical Support
Contact our chemistry experts for bulk pricing or application guidance:
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