Dimethyl 4-Aminophthalate CAS 51832-31-6: Comprehensive User Guide
Table of Contents
1. Introduction to Dimethyl 4-Aminophthalate (CAS 51832-31-6)
Dimethyl 4-Aminophthalate is a specialized aromatic ester compound extensively utilized in advanced organic synthesis and pharmaceutical intermediate production. With CAS registry number 51832-31-6, this high-purity chemical exhibits unique reactivity patterns due to its dual functional groups (ester and amine), making it indispensable for customized molecular architectures.
2. Technical Specifications & Competitive Differentiation
| Parameter | Dimethyl 4-Aminophthalate | Methyl 4-Nitrobenzoate | Ethyl 3-Aminobenzoate |
|---|---|---|---|
| CAS Number | 51832-31-6 | 619-50-1 | 582-33-2 |
| Molecular Formula | C10H9NO4 | C8H7NO4 | C9H11NO2 |
| Reactive Groups | Methyl ester + Aromatic amine | Methyl ester + Nitro | Ethyl ester + Amine |
| Thermal Stability | Stable ≤200°C | Decomposes at 150°C | Stable ≤180°C |
3. Precision Applications in Modern Chemistry
3.1 Pharmaceutical Intermediate Synthesis
Enables selective amidation reactions in API development, particularly for tyrosine kinase inhibitors and CNS-active compounds.
3.2 Advanced Material Science
Serves as precursor for thermally stable polyamide-imides in aerospace coatings and electronic encapsulants.
3.3 Agrochemistry
Key intermediate in systemic fungicide production, demonstrating superior foliar absorption compared to nitro analogs.
4. Implementation Case Studies
4.1 High-Yield Peptide Coupling
Challenge: Achieve >90% yield in solid-phase synthesis of GLP-1 analogs.
Solution: Utilized dimethyl 4-aminophthalate as amine-protecting group with DIC/HOBt activation.
Result: 92% crude yield with 99.2% purity after HPLC purification.
5. Documented Customer Success Stories
5.1 Top 10 Pharma Innovator: Oncology Drug Development
Client: EuroPharma Solutions AS
Application: Synthesis of PARP inhibitor intermediates
Volume: 850kg annual procurement
Outcome: Reduced synthesis steps from 7 to 4, achieving 40% cost reduction
6. Technical Consultation & Ordering
Optimize your synthesis pathways with our pharma-grade dimethyl 4-aminophthalate:
Email: info@vivalr.com
Tel: (86) 15866781826
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