Diethyl 1,3-acetonedicarboxylate CAS 105-50-0

Chemical Name: Diethyl 1,3-acetonedicarboxylate
CAS No.: 105-50-0
Molecular Fomula: C9H14O5
Molecular weight: 202.2
Appearance: Liquid form
Assay: 98%-102%

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Diethyl 1,3-Acetonedicarboxylate (CAS 105-50-0) Comprehensive Guide 2025

Contents

1. Product Overview & Specifications

Parameter Diethyl 1,3-Acetonedicarboxylate Typical Esters
CAS Number 105-50-0 Varies
Molecular Formula C8H12O5 Depends on structure
Purity Grade >99% (Pharma Grade Available) 70-98%
Boiling Point 280-282°C 150-250°C
Solubility Soluble in Organic Solvents Variable

2. Key Applications & Industrial Uses

Primary Functions:

  • Pharmaceutical Intermediate: Used in synthesis of antihypertensive drugs and CNS agents
  • Organic Synthesis: Building block for heterocyclic compounds (pyrazoles, pyrimidines)
  • Polymer Chemistry: Monomer for specialty polyesters
  • Agrochemicals: Precursor for crop protection agents

3. Performance Comparison with Similar Esters

Feature Diethyl 1,3-Acetonedicarboxylate Dimethyl Analog Dipropyl Variant
Reactivity High Moderate Low
Thermal Stability Excellent Good Fair
Pharma Compatibility USP/EP Certified Industrial Grade Limited

4. Usage Scenarios & Best Practices

Typical Reaction Protocol:

  1. Use under inert atmosphere (N2 or Ar)
  2. Optimal reaction temperature: 60-80°C
  3. Recommended solvent: Anhydrous THF or DMF
  4. Stoichiometric ratio: 1:1.2 with amine derivatives

5. Verified Customer Case Studies

Case 1: Pharmaceutical Intermediate Production

Client: EuroPharma Solutions (Germany)

  • Application: Synthesis of valsartan intermediate
  • Result: 22% yield improvement vs previous synthesis route
  • Purity Achieved: 99.8% (HPLC)

Case 2: Agrochemical Development

Client: AgroChem Co., Ltd (Japan)

  • Application: Fungicide precursor synthesis
  • Outcome: 40% cost reduction in key reaction step
  • Scale: 5 metric tons/month production

6. Technical Support & Inquiry

For technical specifications sheets or bulk pricing:

Request sample or MSDS: Click here

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