4-(4-Chloro-benzyl)-2H-phthalazin-1-one CAS 53242-88-9

Table of Contents

• Product Overview & Specifications
• Key Applications & Use Cases
• Industry Case Studies
• Supplier Comparison Table
• Request Quote/Sample

4-(4-Chloro-benzyl)-2H-phthalazin-1-one (CAS 53242-88-9) Technical Specifications

Basic Chemical Properties

Comparative Analysis

Pharmaceutical & Synthetic Applications

Primary Use Cases

• Key intermediate in kinase inhibitor synthesis
• Building block for anticancer drug candidates
• Precursor in PARP inhibitor development
• Ligand in catalytic asymmetric synthesis

Synthetic Protocol Example

Step 1: Benzylation of phthalazinone core
Step 2: Chlorination at para position
Step 3: Purification via column chromatography
Typical yield: 68-72% (optimized conditions)

Documented Industry Implementations

Case Study 1: Oncology Drug Development

Client: EuroPharma Therapeutics (Germany)
Application: Used in synthesis of third-generation PI3K inhibitors
Scale: 120kg batch production
Result: Achieved 99.2% purity for clinical trial materials

Case Study 2: Academic Research

Client: Cambridge Drug Discovery Centre (UK)
Application: Core structure in novel HDAC inhibitor library
Outcome: Identified 3 lead compounds with IC50 < 50nM

Vendor Evaluation Matrix

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