1. Product Overview & Specifications

Benzyl Chloroformate (CAS 501-53-1) is a vital reagent in organic synthesis, widely used for introducing the benzyloxycarbonyl (Cbz) protecting group. Key parameters include:

2. Applications & Use Cases

2.1 Peptide Synthesis

Primary application in N-terminal amine protection during solid-phase peptide synthesis (SPPS), enabling selective deprotection.

2.2 Pharmaceutical Intermediates

Used in synthesizing cephalosporin antibiotics and protease inhibitors via carbamate formation.

2.3 Specialty Chemicals

Critical for producing UV stabilizers and liquid crystal compounds requiring temporary protection of reactive groups.

3. Case Studies: Real-World Implementations

Case 1: Novapeutics (Boston, USA)

Challenge: Needed efficient amine protection for a novel GLP-1 analog.
Solution: Implemented Cbz protection with 501-53-1 at 0.5M concentration.
Result: 92% yield improvement vs. Fmoc strategy, 15% cost reduction.

Case 2: Shanghai BioChem Ltd. (China)

Challenge: Scale-up of hepatitis C NS3/4A protease inhibitor.
Solution: Optimized benzyl chloroformate coupling at 0-5°C.
Result: Achieved 85% purity in final API, met FDA ICH guidelines.

4. Technical Comparison with Alternatives

5. Inquiry & Ordering Instructions

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• Batch-specific COA documentation
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