4,4′-Dinitrodiphenyl Ether (CAS 101-63-3): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4,4′-Dinitrodiphenyl Ether (CAS 101-63-3) is a nitro-aromatic compound with the molecular formula C₁₂H₈N₂O₅. Widely used as a chemical intermediate, it features two nitro groups attached to a diphenyl ether structure.
Technical Parameters
| Property | Specification | Comparison with Analogues |
|---|---|---|
| Molecular Weight | 260.20 g/mol | Higher than 2-Nitrodiphenyl Ether (215.21 g/mol) |
| Melting Point | 158-160°C | More thermally stable than mono-nitro derivatives |
| Solubility | Insoluble in water, soluble in organic solvents | Similar solubility profile to other nitro-aromatics |
2. Key Applications & Industrial Uses
Primary Applications:
- Pharmaceutical intermediates for antibiotic synthesis
- Agrochemical precursor in herbicide formulations
- Flame retardant additive in polymer production
- Electron-deficient component in organic electronics
3. Usage Guidelines & Best Practices
Handling Procedures:
- Use PPE including nitrile gloves and chemical goggles
- Maintain ventilation below 20°C during storage
- Employ explosion-proof equipment for large-scale reactions
Reaction Optimization:
| Application | Recommended Solvent | Typical Yield |
|---|---|---|
| Nucleophilic Substitution | DMF | 72-85% |
| Catalytic Reduction | Ethanol/Water (3:1) | 90-95% |
4. Practical Use Cases
Case 1: Herbicide Intermediate Production
In a batch process for oxyfluorfen synthesis, 4,4′-Dinitrodiphenyl Ether demonstrated 18% higher reaction efficiency compared to chloro-nitro alternatives.
Case 2: High-Performance Polymer Modification
Polyetherimide formulations incorporating 2% 4,4′-Dinitrodiphenyl Ether showed 40% improvement in thermal stability (Tg increased from 217°C to 235°C).
5. Customer Success Stories
ABC Pharmaceuticals (Germany)
Challenge: Required stable nitro precursor for antitubercular drug R&D
Solution: Implemented CAS 101-63-3 in multi-step synthesis
Result: Achieved 92% purity in final API, reduced process steps by 3
GreenChem Agrosciences (USA)
Challenge: Needed cost-effective alternative for diphenyl ether herbicides
Solution: Transitioned to 4,4′-Dinitrodiphenyl Ether-based formulation
Result: 25% reduction in production costs, maintained 99% weed control efficacy
6. Contact for Technical Support
For material specifications sheets or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Request a free sample or schedule a technical consultation with our chemists.



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