3-Thiophenecarboxaldehyde (CAS 498-62-4) Comprehensive Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 3-Thiophenecarboxaldehyde | Typical Aldehyde Derivatives |
|---|---|---|
| CAS Number | 498-62-4 | Varies by compound |
| Molecular Formula | C5H4OS | CnH2nO |
| Molecular Weight | 112.15 g/mol | 90-150 g/mol |
| Boiling Point | 198°C at 760 mmHg | 150-250°C |
| Flash Point | 73°C (163°F) | 60-100°C |
| Solubility | Miscible with alcohols, ethers; Limited water solubility | Polar solvent compatible |
Key differentiators include enhanced thermal stability and distinct electronic properties due to thiophene heterocycle integration.
2. Functional Applications
This heterocyclic aldehyde serves as critical building block in:
- Pharmaceutical intermediates (ACE inhibitors, antipsychotics)
- Organic electronic materials (OLED charge transport layers)
- Coordination chemistry (ligand synthesis)
- Agrochemical research (pesticide derivatives)
3. Implementation Scenarios
Typical process integration:
- Schiff base formation: Reacts with primary amines at 60-80°C
- Nucleophilic addition: Grignard reagent reactions in THF
- Cross-coupling: Suzuki reactions with aryl boronic acids
4. Industry Case Studies
Case 1: Pharmaceutical Intermediate Production
Wuhan Hongteng Hengrui Chemical utilized 98% purity grade material to develop antihypertensive drug precursors, achieving 92% reaction yield under optimized Buchwald-Hartwig conditions.
Case 2: Organic Semiconductor Development
Shanghai Xinyu Biotech synthesized thiophene-based conjugated polymers showing 15% improved charge mobility compared to furan analogs in OLED prototypes.
5. Procurement Consultation
Available specifications:
- Purity grades: 95%, 98%, 99% (HPLC)
- Packaging: 1kg glass bottles to 200kg HDPE drums
- Custom synthesis: Halogenated derivatives available
Contact technical team for material selection guidance:
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