Benzyl carbamate CAS 621-84-1

Chemical Name: Benzyl carbamate
CAS No.: 621-84-1
Molecular Fomula: C8H9NO2
Molecular weight: 151.16
Appearance: Off-white to light beige powder
Assay: ≥99.0%

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Benzyl Carbamate (CAS 621-84-1) Comprehensive Guide 2025

Product Overview & Specifications

Parameter Benzyl Carbamate Benzyl Chloride Benzyl Alcohol
CAS Number 621-84-1 100-44-7 100-51-6
Molecular Formula C8H9NO2 C7H7Cl C7H8O
Melting Point 86-88°C -43°C -15°C
Applications Pharma Intermediate, Protecting Group Chemical Synthesis Solvent/Disinfectant

Key Applications & Industry Uses

Pharmaceutical Manufacturing

Used as amino-protecting group in peptide synthesis (e.g., Taxol derivatives) to prevent unwanted side reactions during multi-step synthesis.

Polymer Chemistry

Serves as crosslinking agent in specialty resins with 15-20% improved thermal stability compared to traditional benzyl compounds.

Agrochemicals

Key intermediate in slow-release herbicide formulations, enabling 30-day soil persistence for weed control.

Case Study 1: Oncology Drug Intermediate

Client Profile

Top 10 Global Pharma Company (Confidential)

Challenge

Required high-purity (>99.8%) benzyl carbamate for GMP-compliant synthesis of PARP inhibitor candidates.

Solution

Supplied 500kg batches with HPLC-validated purity and <0.1% residual solvent content.

Outcome

Enabled 22% yield improvement in final API step versus previous protecting group strategy.

Case Study 2: High-Performance Resins

Client Profile

Specialty Materials Manufacturer (Public: NYSE listed)

Challenge

Develop fire-resistant aerospace composites requiring 300°C+ thermal stability.

Solution

Custom benzyl carbamate formulation enabling crosslinking density optimization.

Outcome

Achieved UL94 V-0 rating with 320°C HDT in final epoxy system.

Handling & Safety Protocols

Parameter Requirement
Storage 2-8°C in nitrogen atmosphere
PPE Neoprene gloves + Type A respirator
Shelf Life 24 months in original packaging

Supplier Inquiry & Custom Solutions

Request technical specifications or discuss custom synthesis projects:

Our chemical engineers can develop:

  • GMP-grade batches up to 99.95% purity
  • Modified solubility profiles (water-dispersible forms)
  • Kosher/Halal certified material
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