2,5-Thiophenedicarboxylic acid CAS 4282-31-9

Chemical Name: 2,5-Thiophenedicarboxylic acid
Synonyms: 2,5-Dicarboxythiophene
CAS No.: 4282-31-9
Molecular Fomula: C6H4O4S
Molecular weight: 172.16
Appearance: White crystalline powder
Assay: 98%

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Table of Contents

2,5-Thiophenedicarboxylic Acid (CAS 4282-31-9) Overview

Basic Specifications

Parameter Specification
CAS Number 4282-31-9
Molecular Formula C6H4O4S
Molecular Weight 172.16 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Melting Point 280-285°C (dec.)
Solubility Soluble in DMF, DMSO; sparingly soluble in water

Comparative Analysis

Feature 2,5-Thiophenedicarboxylic Acid Other Dicarboxylic Acids
Electron Density High (thiophene ring) Variable
Thermal Stability Excellent (up to 300°C) 200-250°C typical
Coordination Capacity Dual carboxyl groups Single/multiple varies
Pharma Compatibility FDA-approved intermediates Limited applications

Industrial Applications

Pharmaceutical Intermediate

Key component in synthesizing:

  • Tyrosine kinase inhibitors
  • Anticancer drug precursors
  • Non-steroidal anti-inflammatory agents

Advanced Material Science

  • MOFs (Metal-Organic Frameworks)
  • Conductive polymers for OLEDs
  • Coordination polymers

Operational Guidelines

Storage Conditions

Parameter Requirement
Temperature 2-8°C (long-term)
Humidity <40% RH
Light Exposure Amber glass containers

Reaction Protocol

  1. Use anhydrous DMF as solvent
  2. Maintain nitrogen atmosphere
  3. Optimal reaction temperature: 80-100°C

Client Implementations

Case Study 1: Oncology Drug Development

Client: Top 10 Global Pharma Company

  • Application: EGFR inhibitor intermediate
  • Result: 92% yield improvement vs previous synthesis
  • Scale: 500kg batch production

Case Study 2: Flexible Electronics

Client: OLED Manufacturer

  • Application: Electron transport layer material
  • Performance: 15% efficiency increase
  • Patent Status: US 11,235,678 B2

Contact Our Experts

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Custom synthesis available from gram to ton scale.

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