Table of Contents
- Product Overview
- Specifications & Comparison
- Detailed Applications
- Usage Guidelines
- Client Case Studies
- Contact for Technical Consultation
1-(Cyclopropanecarbonyl)piperazine 97% CAS 59878-57-8: Product Overview
Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 59878-57-8 |
| Molecular Formula | C8H12N2O |
| Molecular Weight | 154.20 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥97% (HPLC) |
| Storage | 2-8°C in inert atmosphere |
Technical Advantages
- High thermal stability (decomposition point: 215°C)
- Low hygroscopicity (≤0.8% moisture absorption)
- Pharmaceutical-grade purity (ICH Q7 compliant)
Comparative Analysis with Similar Compounds
| Feature | 1-(Cyclopropanecarbonyl)piperazine | Piperazine Citrate | N-Methylpiperazine |
|---|---|---|---|
| Reactivity | Controlled acylation | High basicity | Moderate nucleophilicity |
| Pharma Applications | API Intermediate | Anthelmintic formulations | Catalyst in synthesis |
Industrial & Pharmaceutical Applications
Key Usage Scenarios
- Antidepressant drug synthesis (SSRI class)
- Peptide coupling reagent in bioconjugation
- Ligand in transition metal catalysis
- Building block for antiviral compounds
Reaction Protocols
| Process | Optimal Conditions |
|---|---|
| Nucleophilic substitution | DCM solvent, 0-5°C, 12h reaction |
| Buchwald-Hartwig coupling | Pd2(dba)3 catalyst, 110°C |
Operational Best Practices
Handling Recommendations
- Use nitrogen-purged environment for storage
- Maximize shelf life through desiccant packs
- Employ glove boxes for moisture-sensitive reactions
Safety Profile
| Parameter | Value |
|---|---|
| Flash Point | 162°C (closed cup) |
| LD50 (oral rat) | 980 mg/kg |
Client Implementation Case Studies
Case 1: European Pharma Innovator
- Client: Top 20 CNS drug manufacturer
- Application: Serotonin modulator intermediate
- Result: 22% yield improvement vs. previous process
Case 2: Asian CRO Specialist
- Scale: 300kg/month production
- Challenge: Minimize genotoxic impurities
- Solution: Custom purification protocol implementation
Technical Consultation & Ordering
For batch-specific COA or custom synthesis requirements:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request GMP certification documentation or MSDS through our 24/7 support portal.
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