L-Histidine Hydrochloride CAS 1007-42-7: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
L-Histidine Hydrochloride (CAS 1007-42-7) is a high-purity amino acid derivative widely used in pharmaceutical, nutraceutical, and biochemical applications. Below are its key parameters:
| Parameter | Specification | Comparison with Standard L-Histidine |
|---|---|---|
| CAS Number | 1007-42-7 | N/A |
| Molecular Formula | C₆H₉N₃O₂·HCl | Includes HCl moiety |
| Purity | ≥99% | Higher solubility |
| Solubility | Water-soluble (50 mg/mL) | Superior to freebase form |
2. Key Applications & Uses
L-Histidine HCl serves critical roles in:
- Pharmaceuticals: Buffer agent in IV formulations, stabilizer for monoclonal antibodies.
- Nutraceuticals: Precursor for histamine synthesis, supports immune function.
- Biochemistry: Cell culture medium additive, enzyme activity studies.
- Cosmetics: Moisturizing agent in skincare products.
3. Usage Guidelines & Best Practices
Recommended Workflow:
- Dissolve in purified water at 20-25°C.
- Adjust pH to 6.5-7.5 for biological applications.
- Filter-sterilize for cell culture use.
Safety Protocols:
- Use PPE (gloves, goggles) during handling.
- Store at 15-30°C in airtight containers.
4. Industry Case Studies
Case 1: Biopharma Buffer Optimization
A leading biologics manufacturer achieved 18% higher antibody stability by replacing standard histidine with L-Histidine HCl in their buffer system.
Case 2: Nutraceutical Formulation
Sports nutrition brand increased product solubility by 40% using our HCl form, reducing tablet disintegration time.
5. Client Success Stories
PharmaBio Inc. (USA)
“Switching to Vivalr’s L-Histidine HCl reduced our buffer preparation time by 35% while meeting strict USP compliance.” – Dr. Emily Tran, Formulation Lead
NutraHealth Solutions (Germany)
“The HCl form resolved our precipitation issues in high-concentration supplements. Batch consistency improved from 78% to 96%.” – Markus Weber, QA Director
6. Contact for Custom Solutions
Request technical specifications, COA, or bulk pricing:
Email: info@vivalr.comPhone: (86) 15866781826
Our experts provide formulation support, regulatory documentation, and sample requests.
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